Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis

Ophthalmic Research
Sindhu Saraswathy, Narsing A Rao

Abstract

In experimental autoimmune uveitis (EAU), the macrophages infiltrate the retina during the late phase, 10-14 days after immunization with uveitogenic antigen, causing photoreceptor damage. However, prior to inflammatory cell infiltration, during the early phase (5-7 days after immunization), increased generation of reactive oxygen and nitric oxide species was observed in the photoreceptor mitochondria indicating oxidative stress. The oxidative-stress-induced nitration of photoreceptor mitochondrial proteins and peroxidation of membrane lipids led to activation and migration of microglia toward the photoreceptors. These observations suggest oxidative stress could be an initial pathologic event leading to amplification of inflammation inducing photoreceptor damage, thereby causing clinical and histologic expression of uveitis in the form of inflammatory cell infiltration.

Citations

Apr 6, 2012·Japanese Journal of Ophthalmology·Yutaka Kaneko, Narsing A Rao
Jan 1, 2010·Journal of Ophthalmic Inflammation and Infection·Angeline M Nguyen, Narsing A Rao
Jun 17, 2011·Brain : a Journal of Neurology·Kenneth J Smith
Jan 31, 2013·International Reviews of Immunology·John V ForresterLucia Kuffova
Sep 5, 2015·Drug Development and Industrial Pharmacy·Jiayu XinHongzhuo Liu
Nov 26, 2010·Journal français d'ophtalmologie·Z DjerabaC Touil-Boukoffa
Jun 30, 2009·Progress in Retinal and Eye Research·Heping XuJohn V Forrester
Dec 9, 2008·Experimental Eye Research·M GoralskaM C McGahan
Dec 6, 2014·Progress in Retinal and Eye Research·Marcus KarlstetterThomas Langmann
Jun 28, 2016·Experimental Eye Research·Ei OhkawaHiroshi Ohguro
Jul 29, 2017·Expert Opinion on Pharmacotherapy·Uwe PleyerReinhold Kreutz
May 10, 2020·International Journal of Molecular Sciences·Sheng-Min HsuShun-Hua Chen
Sep 7, 2021·Experimental Neurobiology·Yuna ChoiTaekyun Shin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Investigative Ophthalmology & Visual Science
Sindhu Saraswathy, Narsing A Rao
Progress in Retinal and Eye Research
Emma C KerrLindsay B Nicholson
Investigative Ophthalmology & Visual Science
Rahul N KhuranaNarsing A Rao
© 2022 Meta ULC. All rights reserved