PMID: 9423992Jan 10, 1998Paper

Photoreceptor orientation and alignment in nasal fundus ectasia

Optometry and Vision Science : Official Publication of the American Academy of Optometry
V LakshminarayananJ M Enoch

Abstract

We investigated whether Stiles-Crawford (SCE) functions, a measure of photoreceptor orientation and alignment, are disturbed in patients with nasal fundus ectasia (tilted disc; Fuch's coloboma without apparent pupillary involvement). SCE functions were obtained in three observers with nasal fundus ectasia, using psychophysical methods. In all cases, disruption of photoreceptor alignment can be inferred. Results include location of the SCE peaks outside the pupil in the direction of the lesion, differential alignment, and reduction of the magnitude of SCE at various retinal loci (reduced curvature or p factor). Additional results obtained with the selective adaptation technique imply that receptor disarray (splaying) may be responsible for loss of retinal directional sensitivity. From these results, it may be surmised that mechanical tractional forces can play a major role in defining photoreceptor orientation in the retina. Inferred anomalous photoreceptor alignment has heretofore not been specifically linked with Fuch's coloboma/tilted disc syndrome.

Citations

Jan 24, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Marilita M MoschosMichael Moschos
Feb 28, 2015·Vision Research·Maria K WalkerNathan Doble
Apr 4, 2007·Acta Ophthalmologica Scandinavica·Marja-Liisa Vuori, Maija Mäntyjärvi
Oct 27, 2015·Vision Research·Hugh J MorrisNathan Doble
Aug 14, 2021·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Vinay Kumar NilagiriDavid A Atchison

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