Photoredox-Catalyzed Diamidation and Oxidative Amidation of Alkenes: Solvent-Enabled Synthesis of 1,2-Diamides and α-Amino Ketones

Organic Letters
Qixue QinShouyun Yu

Abstract

Photoredox-catalyzed difunctionalizations of alkenes with O-acyl hydroxylamine derivatives are described. The solvent tunes the outcome of these reactions. Diamidation and oxidative amidation of alkenes can be achieved in CH3CN and DMSO, respectively. A variety of 1,2-diamidates and α-amino ketones bearing many functional groups are prepared using Ir(ppy)3 as the photocatalyst under visible light irradiation.

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Citations

May 23, 2018·Chemistry : a European Journal·Jacob DaviesDaniele Leonori
Feb 5, 2019·Angewandte Chemie·Qixue QinNing Jiao
Sep 19, 2019·Chemical Communications : Chem Comm·Yong-Hong LiShang-Dong Yang

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