Photorefractive intrastromal corneal crosslinking for treatment of myopic refractive error: Findings from 12-month prospective study using an epithelium-off protocol

Journal of Cataract and Refractive Surgery
Matthias EllingH Burkhard Dick

Abstract

To assess the long-term effectiveness and safety of photorefractive intrastromal corneal crosslinking (CXL) in patients with low myopia. Ruhr University Eye Hospital, Bochum, Germany. Prospective case series. Healthy eyes with myopia were treated with photorefractive intrastromal CXL using the Mosaic System. Riboflavin 0.1% solution (VibeX Rapid) was topically administered, followed by 365 nm ultraviolet-A (30 mW/cm2) irradiance. Efficacy was assessed by the uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), and keratometry. Safety was assessed by corrected distance visual acuity (CDVA), slitlamp biomicroscopy, endothelial cell count, and adverse event rates. Fourteen patients (24 eyes) with a mean age of 35.7 years were included. At all follow-ups, a statistically significant improvement in UDVA was observed (all P < .001). The CDVA progressively improved from 1 month postoperatively and a statistically significant improvement was achieved at 12 months (P < .001). The average reduction in manifest sphere was 0.90 diopter (D) ± 0.40 (SD) by 12 months. There were no significant differences in mean manifest sphere and MRSE at 3, 6, or 12 months. Compared with baseline, significant reductio...Continue Reading

References

Mar 15, 1986·American Journal of Ophthalmology·R H KennedyJ A Dyer
Jan 31, 2003·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G WollensakT Seiler
Oct 3, 2003·Journal of Cataract and Refractive Surgery·Gregor WollensakTheo Seiler
May 26, 2012·Journal of Cataract and Refractive Surgery·David TouboulJoseph Colin
Jul 21, 2012·Journal of Cataract and Refractive Surgery·H Ugur CelikOmer Faruk Yilmaz
Mar 14, 2013·European Journal of Ophthalmology·Ziad HassanGábor Németh
Apr 29, 2014·Journal of Cataract and Refractive Surgery·Ibrahim SevenWilliam J Dupps
Jul 25, 2017·Journal of Cataract and Refractive Surgery·Matthias EllingH Burkhard Dick

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Citations

May 18, 2019·Investigative Ophthalmology & Visual Science·Theo G SeilerKarsten Koenig
Feb 9, 2019·Journal of Cataract and Refractive Surgery·Safa El HoutPierre Fournié
Feb 13, 2020·Scientific Reports·Chimei LiaoMingguang He
Apr 26, 2019·Frontiers in Bioengineering and Biotechnology·Brecken J BlackburnWilliam J Dupps
May 27, 2020·Current Opinion in Ophthalmology·Evan K DackowskiRoy S Chuck
Apr 20, 2021·Klinische Monatsblätter für Augenheilkunde·Stefan J LangThomas Reinhard
May 19, 2021·Translational Vision Science & Technology·Viral V Juthani, Roy S Chuck
Aug 6, 2021·Frontiers in Pharmacology·Duoduo WuChris Hong Long Lim

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