Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: a histologic analysis

Journal of the American Academy of Dermatology
Min Young ParkYou Chan Kim

Abstract

Repeated exposure to ultraviolet radiation from the sun results in premature photoaging. Photodynamic therapy (PDT) has been shown to be effective for treatment of photoaging, although the data from most studies have been based on clinical observation. We investigated whether 5-aminolevulinic acid (ALA)-PDT induced histologic changes suggesting photorejuvenation. Fourteen patients with one to three actinic keratoses on the face were treated twice with ALA-PDT by using a 1200 W metal halogen lamp at 1-month intervals. Skin biopsy before and 1 month after the PDT was performed. Twenty-five pairs of specimens were obtained. We examined the specimens with routine and immunohistochemical staining and evaluated the parameters associated with photoaging by using image analysis. After ALA-PDT, the mean epidermal thickness and dermal inflammatory infiltrate were reduced. The total collagen volume in the dermis significantly increased with expression of type I and III procollagen. The level of transforming growth factor beta and transforming growth factor beta type II receptors in the epidermis also increased. The elastotic material with co-localizing fibrillin-1 and tropoelastin expression in the dermis decreased after treatment. The ex...Continue Reading

References

Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Nov 1, 1989·Journal of the American Academy of Dermatology·W MontagnaK Carlisle
Aug 1, 1994·The Journal of Investigative Dermatology·E F BernsteinJ Uitto
Feb 5, 1998·Experimental Dermatology·V M Kähäri, U Saarialho-Kere
Jun 16, 2001·The Journal of Investigative Dermatology·J Y SeoJ H Chung
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Jun 13, 2002·The Journal of Dermatological Treatment·R-M SzeimiesS Karrer
Aug 23, 2002·The Journal of Investigative Dermatology·Jin Ho ChungJohn J Voorhees
Jan 25, 2003·The Journal of Investigative Dermatology·Sigrid KarrerRolf-Markus Szeimies
Jul 16, 2005·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Ellen S MarmurDavid J Goldberg
Oct 19, 2005·Archives of Dermatology·Jeffrey S DoverKenneth A Arndt
Jan 18, 2006·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Nicholas J Lowe, Philippa Lowe
Jan 3, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Ellie Shihng Meir ChuChristine Miu Ngan Yow
Oct 22, 2008·Archives of Dermatology·Jeffrey S OrringerJohn J Voorhees

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Citations

May 11, 2012·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P Babilas, M Landthaler
Feb 28, 2015·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Daniel P FriedmannIsabella Guiha
Jun 27, 2012·Expert Opinion on Drug Delivery·Nina Dragicevic-Curic, Alfred Fahr
Nov 15, 2013·Annales de dermatologie et de vénéréologie·Ch Bédane
Jan 23, 2013·The Journal of Investigative Dermatology·Yong Hyun JangYou Chan Kim
Nov 30, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Sigrid KarrerRolf-Markus Szeimies
May 29, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K Togsverd-BoM Haedersdal
Jun 23, 2015·International Journal of Dermatology·Moetaz El-DomyatiHanna Farag
Dec 18, 2014·International Journal of Dermatology·Moetaz El-DomyatiJouni Uitto
Dec 3, 2014·Photodiagnosis and Photodynamic Therapy·Duoqin WangLianjun Chen
Jul 8, 2016·Archives of Dermatological Research·Sue Kyung KimYou Chan Kim
Oct 25, 2016·Methods : a Companion to Methods in Enzymology·Pablo Fonda-PascualPedro Jaen-Olasolo
Mar 31, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Wolfgang G Philipp-Dormston
Feb 19, 2010·Lasers in Surgery and Medicine·Matteo Tretti ClementoniGirish S Munavalli
Dec 30, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Anne Le Pillouer-Prost, Hugues Cartier
Apr 30, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Daniel P Friedmann, Mitchel P Goldman
Dec 15, 2018·Journal of Cosmetic Dermatology·Mohamed AmerRana Mahmoud
Oct 19, 2017·Pigment Cell & Melanoma Research·Sue Kyung KimYou Chan Kim
May 13, 2018·American Journal of Clinical Dermatology·Colin A Morton, Lasse R Braathen
Feb 25, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alisen HuangJared Jagdeo
Jan 12, 2021·Photodiagnosis and Photodynamic Therapy·Linglin ZhangXiuli Wang
Jun 20, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Giuseppe MonfrecolaPiergiacomo Calzavara-Pinton

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