Photoresponsive Block Copolymer Prodrug Nanoparticles as Delivery Vehicle for Single and Dual Anticancer Drugs

ACS Omega
Gargi BiswasDibakar Dhara

Abstract

In recent decades, drug delivery systems (DDSs) based on polymer nanoparticles have been explored due to their potential to deliver drugs with poor water solubility. Some of the limitations of nanoparticle-based DDSs can be overcome by developing an appropriate polymer prodrug. In this work, poly(NIPA)-b-poly(HMNPPA)-b-poly(PEGMA-stat-BA) was synthesized using reversible addition fragmentation chain transfer polymerization and Chlorambucil (Cbl), an anticancer drug, was conjugated to the copolymer via 3-(3-(hydroxymethyl)-4-nitrophenoxy)propyl acrylate (HMNPPA) units to prepare the prodrug. A few biotin acrylate (BA) units were also incorporated to bring potential targeting capability to the prodrug in the copolymer. This polymer prodrug formed spherical micellar nanoparticles in physiological conditions, which were characterized by dynamic light scattering and transmission electron microscopy measurements. The very low critical aggregation concentration (cac) (0.011 mg/mL) of the prodrug, as measured from Nile Red fluorescence, makes it stable against dilution. The polymer prodrug was shown to release Cbl on photoirradiation by soft UV (λ ≥ 365 nm) and laser (λ = 405 nm) light. The prodrug micellar nanoparticles were capable o...Continue Reading

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Citations

Sep 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoxiao ShiZhigang Xu
Jun 1, 2021·ACS Applied Bio Materials·Lai Jiang, Say Chye Joachim Loo
Sep 29, 2021·Soft Matter·Virna M Martín GiménezWalter Manucha

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Datasets Mentioned

BETA
MB-231

Methods Mentioned

BETA
irradiating
column chromatography
NMR
transmission
dynamic light scattering
MDA
light scattering
Fluorescence
confocal microscopy

Related Concepts

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