Photoresponsive molecular tools for emerging applications of light in medicine.

Chemical Science
Ilse M WellemanWiktor Szymanski

Abstract

Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely on molecular tools, such as photocleavable protecting groups and photoswitches that respond to photonic stimulus and translate it into a biological effect. However, optimisation of their key parameters (activation wavelength, band separation, fatigue resistance and half-life) is necessary to enable application in the medical field. In this perspective, we describe the applications scenarios that can be envisioned in clinical practice and then we use those scenarios to explain the necessary properties that the photoresponsive tools used to control biological function should possess, highlighted by examples from medical imaging, drug delivery and photopharmacology. We then present how the (photo)chemical parameters are currently being optimized and an outlook is given on pharmacological aspects (toxicity, solubility, and stability) of light-responsive molecules. With these interdisciplinary insights, we aim to inspire the future directions for the development of photocontrolled tools that will empower clinical applications of light.

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Citations

Mar 4, 2021·ACS Infectious Diseases·Inga S ShchelikKarl Gademann
Apr 29, 2021·Chemical Communications : Chem Comm·Piermichele KobauriBen L Feringa
May 6, 2021·Organic & Biomolecular Chemistry·Andrey G Lvov, Aleksei Bredihhin
Jun 12, 2021·Cell Chemical Biology·Martin Reynders, Dirk Trauner
Jul 3, 2021·Cancers·Petra Dunkel, Janez Ilaš
Sep 11, 2021·Chemical Communications : Chem Comm·Yongjin XuMorten Grøtli
Sep 14, 2021·Chemical Communications : Chem Comm·Nawel GoualArnaud Voituriez
Oct 1, 2021·Chemical Society Reviews·Jana VolarićBen L Feringa
Oct 12, 2021·Organic & Biomolecular Chemistry·Chenghong ZhuYan Zhang
Nov 19, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Olivier GalangauStéphane Rigaut

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