Photoresponsive Nanovehicle for Two Independent Wavelength Light-Triggered Sequential Release of P-gp shRNA and Doxorubicin To Optimize and Enhance Synergistic Therapy of Multidrug-Resistant Cancer

ACS Applied Materials & Interfaces
Ming WuJingfeng Liu

Abstract

Prerelease of RNA molecules than chemotherapeutic drugs with a sufficient interval is a vital prerequisite for RNA/drug co-delivery strategy to overcome multidrug resistance (MDR) of cancer cells, but how to precisely control their release at different time points is still a grand challenge up to now. This study aims to on-demand remotely manipulate RNA and drug release in real time through single delivery system to sequentially play their respective roles for optimizing and enhancing their synergistic antitumor effects. To this end, a photoresponsive mesoporous silica nanoparticle (PMSN) is fabricated as a co-delivery vehicle of P-glycoprotein (P-gp) short-hairpin RNA (shRNA) and photocaged prodrug of doxorubicin (DOX), by which the orthogonal and sequential release of shRNA and DOX can be achieved using an external light. In our design, the cationic poly[2-( N, N-dimethylaminoethyl)methacrylate] is introduced onto the PMSN surface through a light-sensitive coumarin ester derivative linker to adsorb P-gp shRNA, whereas the photocleavable o-nitrobenzyl ester derivative-caged DOX is loaded into the inner pores of the PMSN. The PMSN is found to be effectively internalized by MDR cancer cells, and the release of the shRNA and DOX ...Continue Reading

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Citations

Mar 28, 2019·Angewandte Chemie·Jan P MenzelChristopher Barner-Kowollik
Nov 2, 2019·Angewandte Chemie·Nathaniel CorriganCyrille Boyer
Sep 16, 2020·Journal of Biophotonics·Sepanta Hosseinpour, Laurence J Walsh
Oct 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mengshi JiangJian You
Apr 17, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ya-Xuan ZhuFu-Gen Wu
Jun 3, 2021·Pharmaceutics·Yuseon ShinKyungtaek Oh
May 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shangui LiuGuangxi Zhai
Jun 28, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan LiangShu-Yang Xie
Aug 14, 2020·Nano Today·Sepideh AhmadiMichael R Hamblin

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