Photosensitization of the endometrium with topical 5-aminolevulinic acid

American Journal of Obstetrics and Gynecology
M J GannonR J Lilford

Abstract

Photosensitization of the endometrium was attempted in vitro and in vivo by intrauterine administration of 5-aminolevulinic acid, which is converted to the photosensitizer protoporphyrin IX. Protoporphyrin IX was found in both functional and basal layers of the endometrial glands at concentrations nine and 10 times higher than myometrium in in vitro and in vivo experiments, respectively. Selective endometrial photosensitization is possible with topical 5-aminolevulinic acid, but it might not be distributed sufficiently evenly for use as a sensitizing agent in photodynamic ablation.

References

Nov 1, 1994·American Journal of Obstetrics and Gynecology·P WyssY Tadir

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Citations

Jan 24, 1998·Journal of Photochemistry and Photobiology. B, Biology·B N RoyR L Reid
Mar 1, 2005·Photodiagnosis and Photodynamic Therapy·R R AllisonC H Sibata
Dec 28, 1999·British Journal of Obstetrics and Gynaecology·M J Gannon, S B Brown
Feb 1, 1997·Photochemistry and Photobiology·Q PengJ M Nesland
Oct 26, 2005·Gastrointestinal Endoscopy·Thomas ZöpfJoachim C Arnold
Jan 5, 2001·Expert Opinion on Investigational Drugs·S B BrownD I Vernon
Aug 2, 2000·American Journal of Obstetrics and Gynecology·P HillemannsM Korell

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