Photosensitization with anticancer agents. 20--EPR studies on the photodynamic action of phleichrome: formation of semiquinone radical and activated oxygen species on illumination with visible light

Free Radical Biology & Medicine
Z Diwu, J W Lown

Abstract

When phleichrome was illuminated with visible light, the semiquinone radical, singlet oxygen, and superoxide anion radical were detected. The formation of the semiquinone radical and activated oxygen species and the transformations and competitions between them depend on quinone and oxygen concentration, duration and intensity of illumination, and the nature of the substrate. In anaerobic solution, the semiquinone radical was predominantly photoproduced via the self-electron transfer between the excited and ground species. In contrast, in aerobic solution, singlet oxygen is the principal product in the photosensitization of phleichrome. In addition to singlet oxygen, superoxide anion radical is also generated by the quinones upon illumination in aerobic solution, but to a lesser extent. The generation of the superoxide anion is significantly enhanced by the presence of electron donors.

References

Jul 14, 1978·Biochemical and Biophysical Research Communications·G R Buettner, L W Oberley
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Feb 1, 1991·Photochemistry and Photobiology·S Carpenter, G A Kraus
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Jan 1, 1994·Pharmacology & Therapeutics·Z Diwu, J W Lown
May 31, 1979·Nature·J Moan, E Wold

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Citations

Jul 26, 2003·Biochimica Et Biophysica Acta·M RajendranR Murugesan
Jun 3, 2000·Journal of Photochemistry and Photobiology. B, Biology·A ColasantiF Villani
Jun 1, 1995·Photochemistry and Photobiology·Z Diwu

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