Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression

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Ting WangShaohua Wei

Abstract

Reactive oxygen species (ROS) generated during photodynamic therapy (PDT) can trigger autophagy. However, little research is focused on whether there is a synergistic anticancer effect with PDT if extra autophagy promoter or inhibitor is added. Here, it is found that autophagy promotion significantly enhances the PDT activity to cancer cells. Based on this preliminary result, a ROS-sensitive self-assembled dendrimer nanoparticle is exploited as a carrier to codeliver an autophagy promoter (rapamycin, Rapa) and photosensitizer (phthalocyanine, Pc) to the tumor. After entrapped by cancer cells and irradiated by light, the ROS generated in PDT process of Pc can trigger nanoparticle destruction to release Rapa, thus initiating the autophagy process and remarkably enhancing the efficacy of PDT, leading to efficient tumor suppression.

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Citations

Nov 8, 2018·International Journal of Molecular Sciences·Chul Won Yun, Sang Hun Lee
Dec 6, 2018·Pharmaceuticals·Tuanwei Li, Lifeng Yan
Dec 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen QinQuankui Lin
May 22, 2020·Seminars in Cancer Biology·Itishree KaushikSanjay K Srivastava
Oct 31, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Chen QinQuankui Lin
Jul 6, 2021·Chemical Society Reviews·Jianlei XieJong Seung Kim

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