Photosensitizers binding to nucleic acids as anticancer agents

Future Medicinal Chemistry
Luigi E XodoValentina Rapozzi

Abstract

Cationic porphyrins (Prs) and phthalocyanines (Pcs) are strong photosensitizers that have drawn much attention for their potential in photodynamic therapy. These compounds have the interesting property of binding to nucleic acids, in particular G-rich quadruplex-forming sequences in DNA and RNA. In this review, we highlight their potential as anticancer drugs.

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Citations

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Methods Mentioned

BETA
fluorescence microscopy
confocal microscopy
electrophoresis
FRET

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