Photosensitizing Activity of Endogenous Eye Lens Chromophores: An Attempt to Unravel Their Contributions to Photo-Aging and Cataract Disease

Photochemistry and Photobiology
Felipe AvilaEduardo Silva

Abstract

UVA-visible light has been proposed as a risk factor in the photo-aging of the human eye lens, as well as in the etiology of cataract disease. There is accumulating evidence indicating that photosensitizing reactions mediated by endogenous chromophores, which are generated during human eye lens aging, can play an important role in the generation of these processes. These reactions can lead to protein impairment by inducing non-enzymatic post-translational modifications such as protein oxidation and crosslinking. Although numerous chromophores have been characterized as both bound to human eye lens proteins and as unbound low-molecular-mass compounds, their contribution to eye lens photoaging and cataract disease is not completely understood. In this article we discuss the photochemical contribution of UV-filters derived from tryptophan catabolism and advanced glycation end products (AGEs) to human eye lens aging and cataract disease. We also discuss the recently described photosensitizing capacity of chromophores derived from newly discovered glucose and ascorbate degradation as a parallel pathway to their role in AGEs generation.

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Citations

Jul 23, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Melisa D Marquioni-Ramella, Angela M Suburo
Dec 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Felipe ÁvilaEduardo Silva
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Feb 23, 2018·Experimental Eye Research·Mark Bree, Douglas Borchman
Jul 1, 2021·Journal of Photochemistry and Photobiology. B, Biology·Victoria Eugenia LledóAna Guzman-Aranguez

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