Photostability of barnidipine in combined cyclodextrin-in-liposome matrices

Future Medicinal Chemistry
G IoeleG Ragno

Abstract

The improvement of barnidipine photostability was investigated in cyclodextrin or liposome matrices and in appropriate combinations of these matrices. These supramolecular systems allowed the preparation of liquid formulations, as an alternative to the current solid commercial specialties. Photodegradation stressing tests were performed according to the ICH rules and monitored by derivative spectrophotometry. Optimization was evaluated in terms of drug-inclusion efficiency. The photodegradation rate of barnidipine in ethanol proved rapid (residual percentage of 29.81%) after a radiation exposure of 225 kJ/m(2). The residual concentrations detected for liposome and cyclodextrin complexes were 42.90 and 72.03%, respectively. The best results were obtained when the drug-cyclodextrin complex was in turn entrapped in liposomes (residual percentage of 90.78%). The stability of the drug-in-cyclodextrin-in-liposome system increased significantly with a value close to that of solid formulations whose residual percentage was 96.03%.

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Citations

Jun 7, 2014·Journal of Pharmaceutical and Biomedical Analysis·Marzena JamrógiewiczMichał Strankowski
Nov 19, 2015·Future Medicinal Chemistry·Giuseppina IoeleGaetano Ragno
Apr 18, 2016·International Journal of Pharmaceutics·Michele De LucaGaetano Ragno
May 26, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Iqbal AhmadArif Sabah
Sep 1, 2017·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Miyase Gözde GündüzGiuseppina Ioele
Oct 27, 2017·Drug Delivery·Giuseppina IoeleGaetano Ragno
Sep 28, 2017·Anais Da Academia Brasileira De Ciências·Fernando C SilvaGrácia D F Silva
Sep 15, 2017·AAPS PharmSciTech·Karthik Yadav JangaS Narasimha Murthy
Mar 25, 2019·Journal of Food Science and Technology·Claudia SpatariMichele De Luca
Oct 29, 2020·Physical Chemistry Chemical Physics : PCCP·Sharmistha Dutta Choudhury, Haridas Pal

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Methods Mentioned

BETA
gel filtration

Software Mentioned

UV Winlab

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