Photostable 1-Trifluoromethyl Cinnamyl Alcohol Derivatives Designed as Potential Fungicides and Bactericides.

Journal of Agricultural and Food Chemistry
Meng ZhangRanfeng Sun

Abstract

In the current work, a series of 1-trifluoromethyl cinnamyl alcohol derivatives were designed and synthesized and their antifungal activities were evaluated. The bioassay result showed that most compounds exhibited excellent antifungal activity in vitro at 10 μg mL-1. Next, photostable and easily synthesized compound 2 with broad-spectrum antifungal activity in vitro was selected as a potential candidate to evaluate its antibacterial and antifungal activities. The EC50 values of compound 2 against eight fungal plant pathogens in vitro ranged from 3.806 to 17.981 μg mL-1; at the same time, compound 2 could effectively control Podosphaera xanthii, Odium heveae Steinm, Puccinia striiformis West, and Puccinia sorghi in pot experiments. In addition, compound 2 exhibited excellent antibacterial activities in vitro and in vivo against Xanthomonas oryzae pv. oryzae. Furthermore, the absorption and translocation of compound 2 in wheat plants were determined by the high-performance liquid chromatography method. The result showed that compound 2 could be translocated acropetally as well as basipetally in wheat plants. Finally, it was found that compound 2 had no cross-resistance with carbendazim, azoxystrobin, and boscalid.

References

Aug 11, 2017·Journal of Agricultural and Food Chemistry·Mengmeng TongRuyan Hou
Mar 6, 2019·Environmental Science & Technology·Jochen P ZubrodRalf B Schäfer
Apr 18, 2019·Biochemical and Biophysical Research Communications·Yinggen KeShiping Wang
May 29, 2019·Journal of Agricultural and Food Chemistry·Chao JuYunlong Yu
Aug 4, 2019·Ecotoxicology and Environmental Safety·Wenfeng WangXiangyang Yu
Sep 19, 2019·Journal of Agricultural and Food Chemistry·Xiangmin SongRanfeng Sun
Oct 11, 2019·Beilstein Journal of Organic Chemistry·Xiaowei LiDayong Shi
Nov 8, 2019·Journal of Agricultural and Food Chemistry·Dongyan YangTatiana V Glukhareva
Nov 28, 2019·The Science of the Total Environment·Chao JuYunlong Yu
Mar 20, 2020·Journal of Agricultural and Food Chemistry·Pan TaoJie Song
Mar 23, 2020·Bioorganic & Medicinal Chemistry Letters·Qiong WuBaoan Song
Sep 18, 2020·Journal of Agricultural and Food Chemistry·Xiaodan YinYing-Qian Liu

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