Photosynthetic growth despite a broken Q-cycle.

Nature Communications
Alizée MalnoëFabrice Rappaport

Abstract

Central in respiration or photosynthesis, the cytochrome bc(1) and b(6)f complexes are regarded as functionally similar quinol oxidoreductases. They both catalyse a redox loop, the Q-cycle, which couples electron and proton transfer. This loop involves a bifurcated electron transfer step considered as being mechanistically mandatory, making the Q-cycle indispensable for growth. Attempts to falsify this paradigm in the case of cytochrome bc(1) have failed. The rapid proteolytic degradation of b(6)f complexes bearing mutations aimed at hindering the Q-cycle has precluded so far the experimental assessment of this model in the photosynthetic chain. Here we combine mutations in Chlamydomonas that inactivate the redox loop but preserve high accumulation levels of b(6)f complexes. The oxidoreductase activity of these crippled complexes is sufficient to sustain photosynthetic growth, which demonstrates that the Q-cycle is dispensable for oxygenic photosynthesis.

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Citations

Oct 29, 2013·Photosynthesis Research·Taras K AntalEsa Tyystjärvi
Jul 23, 2013·Current Opinion in Structural Biology·Fei SunZihe Rao
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Aug 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·J L YulyD N Beratan
Jan 19, 2021·Biochimica Et Biophysica Acta. Bioenergetics·Lorna A MaloneMatthew P Johnson

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