Phototherapy in atopic dermatitis: a systematic review of the literature

Actas dermo-sifiliográficas
A Pérez-FerriolsI García-Doval

Abstract

Phototherapy is a treatment option for atopic dermatitis recommended by several guidelines. To perform a systematic review of the efficacy of different modalities of phototherapy and photochemotherapy in moderate to severe atopic dermatitis. We considered all randomized clinical trials (RCTs) performed in patients with atopic dermatitis, and accepted all outcome measures. Articles were identified via an online search of the MEDLINE (via Ovid) and Embase databases and the Cochrane Central Register of Controlled Trials. We also searched for clinical trials registered in Current Controlled Trials and in the World Health Organization's International Clinical Trials Registry Platform. Twenty-one RCTs (961 patients) were included in the qualitative analysis. Two of the trials included children and adolescents (32 patients). The efficacy of narrow-band UV-B and UV-A1 phototherapy was similar for the different outcome measures contemplated. Two RCTs assessed the efficacy of psoralen plus UV-A therapy (PUVA). No serious adverse events were described. In general, the publications reviewed were characterized by a high risk of bias and poor reporting of methodology and results. There is evidence for the use of narrow-band UV-B and UV-A1 ph...Continue Reading

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Citations

Sep 18, 2018·Journal of Cutaneous Medicine and Surgery·Matthew HumRobert Gniadecki
Nov 23, 2020·Archives of Dermatological Research·Marissa T AyasseJonathan I Silverberg
Oct 29, 2021·The Cochrane Database of Systematic Reviews·Annelie H MustersPhyllis I Spuls

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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