Photothermal Fenton Nanocatalysts for Synergetic Cancer Therapy in the Second Near-Infrared Window.

ACS Applied Materials & Interfaces
Haitao SunHangrong Chen

Abstract

Chemodynamic therapy (CDT) that utilizes endogenous hydrogen peroxide (H2O2) to produce reactive oxygen species (ROS) to kill cancer cells has shown a promising strategy for malignant tumor treatment. Nevertheless, limited H2O2 levels in the tumor microenvironment often compromise the therapeutic benefits of CDT, leading to cancer recurrence and metastasis. Herein, a second near-infrared (NIR-II) photothermal Fenton nanocatalyst (PFN) was developed for activatable magnetic resonance imaging (MRI)-guided synergetic photothermal therapy (PTT) and CDT of pancreatic carcinoma. Such a PFN consists of manganese dioxide (MnO2), copper sulfide (CuS), and human serum albumin (HSA), which serve as the activatable imaging contrast agent, the NIR-II photothermal agent and Fenton catalyst, and the stabilizer, respectively. The acidic tumor microenvironment increased the relaxivity of PFN by 2.1-fold, allowing for improved imaging performance and monitoring of nanoparticle accumulation in tumors. Under NIR-II laser irradiation at 1064 nm, PFN generates local heat, which not only permits PTT but also enhances the nanocatalyst-mediated Fenton-like reaction. As such, PFN exerts a synergetic action to completely ablate xenografted tumor models i...Continue Reading

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Citations

Nov 26, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ya-Nan HaoJian-Hua Wang
Nov 28, 2020·Chemical Society Reviews·Cheng Xu, Kanyi Pu
Oct 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haroon IqbalHuabing Chen
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Nov 2, 2021·Frontiers in Bioengineering and Biotechnology·Bin HuangJianfeng Chu
Feb 7, 2022·Journal of Nanobiotechnology·Yandong WangYanyan Jiang

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