Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Peijing AnBaiwang Sun

Abstract

Tumor microenvironment (TME)-responsive nanoformulations that catalyze a cascade of intracellular redox reactions showed promise for tumor treatment with high specificity and efficiency. In this study, we report Cu2+-doped zeolitic imidazolate frameworks-coated polydopamine nanoparticles (PDA@Cu/ZIF-8 NPs) for glutathione-triggered and photothermal-reinforced sequential catalytic therapy against breast cancer. In the TME, the PDA@Cu/ZIF-8 NPs could initially react with antioxidant glutathione (GSH), inducing GSH depletion and Cu+ generation. Whereafter, the generated Cu+ would catalyze local H2O2 to produce highly toxic hydroxyl radicals (·OH) through an efficient Fenton-like reaction even in weakly acidity. Importantly, the PDA could exert excellent photothermal conversion effect to simultaneously accelerate GSH consumption and improve the Fenton-like reaction for further expanding the intracellular oxidative stress, which innovatively achieves a synergistic photothermal-chemodynamic therapy for highly efficient anticancer treatment.

Citations

Apr 11, 2020·Materials·Daniel HauserBarbara Rothen-Rutishauser
Oct 29, 2020·Chemical Society Reviews·Jiajie ChenJianlin Shi
Nov 26, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ya-Nan HaoJian-Hua Wang
Feb 27, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jiahui LuJingjing Li
Jan 1, 2021·Colloids and Surfaces. B, Biointerfaces·Dihai GuBaiwang Sun
Aug 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiang-Long TangHong-Yi Liu
Sep 21, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shu ShengXuesi Chen
Apr 1, 2021·ACS Applied Materials & Interfaces·Ping DongXiaoqing Liu
Apr 18, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Huizi DengQi Shen
Jun 3, 2021·International Journal of Molecular Sciences·Ying SunHao Hu
Jun 30, 2021·Journal of Nanobiotechnology·Jingqi XinFeifei An
Jan 19, 2021·ACS Biomaterials Science & Engineering·Xiao LiuHaijun Yu
Nov 9, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min LiuBaiwang Sun

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