PMID: 2121943Jun 1, 1990Paper

Photothermal sensitizers: possible use in tumor therapy

Journal of Photochemistry and Photobiology. B, Biology
G Jori, J D Spikes

Abstract

Photothermal damage of tissues or endotissular compartments may be induced by pulsed irradiation of either endogenous chromophores (e.g. hemoglobin, melanin) or externally added dyes; the latter should have short triplet lifetimes and mainly decay from electronically excited states by nonradiative pathways. Potential photothermal sensitizers are some metallo derivatives of porphyrins and porphyrinoid compounds, azo dyes and triphenylmethane derivatives. These dyes have the additional property of significant absorbance at wavelengths longer than 600 nm, which can penetrate deep into biological tissues. Spatial confinement of the photothermal process depends on the absorption coefficient of the photoexcited chromophore and its thermal relaxation time. Present evidence indicates that the selective photothermal damage of macromolecules or subcellular organelles requires pulsed excitation at picosecond or nanosecond regimes, while microsecond or millisecond domains are effective in the case of cells or similar structures. The possible use of photothermal sensitization in the treatment of tumors is briefly discussed.

References

Jun 1, 1989·Journal of Photochemistry and Photobiology. B, Biology·B C Wilson, J E van Lier
Jun 1, 1987·Photochemistry and Photobiology·T J Dougherty
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D G Jay
Apr 1, 1986·Physics in Medicine and Biology·B C Wilson, M S Patterson
Jan 1, 1986·Lasers in Surgery and Medicine·J G MorelliJ A Parrish
Jan 1, 1985·Lasers in Surgery and Medicine·L O SvaasandM Oeveraasen
Dec 1, 1981·Photochemistry and Photobiology·S WanM Madden

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Citations

Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
Jun 20, 2013·Pharmaceutical Research·Ruchika FernandoAshish Ranjan
Jan 1, 1994·Pharmacology & Therapeutics·Z Diwu, J W Lown
Mar 10, 2001·Journal of Photochemistry and Photobiology. B, Biology·M BuckingG Weagle
Feb 15, 2000·Journal of Photochemistry and Photobiology. B, Biology·A BusettiG Jori
Sep 23, 2010·Advanced Drug Delivery Reviews·Prakash RaiTayyaba Hasan
Aug 14, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rong Tong, Daniel S Kohane
May 21, 2014·Angewandte Chemie·Thomas D MacDonaldGang Zheng
Jun 9, 2015·Lasers in Surgery and Medicine·Heyke C Diddens-TschoekeHenning Hanken
Jan 28, 2014·Advanced Healthcare Materials·Cheng S JinGang Zheng
Jun 12, 2013·Advanced Drug Delivery Reviews·Shanmugamurthy LakshmananMichael R Hamblin
Oct 1, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Monica CamerinLuca Prodi
Nov 22, 2007·Applied Spectroscopy·Anton V BrusnichkinVladimir P Zharov
Jul 19, 2002·Lasers in Surgery and Medicine·Dmitri O LapotkoVladimir P Zharov
Aug 26, 2014·Chemistry : a European Journal·Graeme T SpenceBradley D Smith
Dec 1, 1991·Photochemistry and Photobiology·J D Spikes
Feb 7, 2015·Advanced Materials·Chunyan BaoHe Tian
Jan 29, 2021·Biomedicines·Su Woong YooEuiheon Chung
Jun 9, 2005·Chemical Reviews·Konrad SzaciłowskiGrazyna Stochel
Jul 29, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Leonardo BianchiPaola Saccomandi

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