Photothermal therapy with AuNRs and EGFRmAb-AuNRs inhibits subcutaneous transplantable hypopharyngeal tumors in nude mice

International Journal of Oncology
Yingying ZhangXiaoguang He

Abstract

The present study aimed to investigate the effects of photothermal therapy with gold nanorods (AuNRs) or epidermal growth factor receptor monoclonal antibody‑conjugated AuNRs (EGFRmAb‑AuNRs) on hypopharyngeal carcinoma (HC) in nude mice. In addition, the associated signaling pathways were explored. Briefly, a subcutaneous transplantable hypopharyngeal tumor model was established in nude mice injected with FaDu human HC cells. A total of 70 nude mice were randomly divided into seven groups, each of which received a different treatment. Mice were treated with AuNRs, locally or through intravenous injection, whereas EGFRmAb or EGFRmAb‑AuNRs were only administered locally. Near infrared spectroscopy (NIR) was also applied for plasmonic photothermal therapy (PPTT). The growth curve and the inhibitory rate for tumor growth were used to evaluate the effects of each treatment. Flow cytometry and the terminal‑deoxynucleotidyl transferase dUTP nick end labeling assay were adopted to detect apoptosis of cells in the transplanted tumors. Reverse transcription‑quantitative polymerase chain reaction and western blotting were used to determine the mRNA and protein expression levels of target genes, respectively. Local treatment with AuNRs + N...Continue Reading

References

Sep 7, 2001·Genes & Development·R T Abraham
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 11, 2002·The Journal of Bone and Joint Surgery. American Volume·Elke AhlmannPaul Holtom
Dec 27, 2005·Gene·Nicola NormannoDavid S Salomon
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
May 19, 2006·Cancer Research·Carole SourbierThierry Massfelder
Oct 20, 2007·Expert Review of Anticancer Therapy·Dexin Zhang, Daiming Fan
Jan 2, 2008·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jaclyn LoPiccoloPhillip A Dennis
Feb 22, 2008·Current Medicinal Chemistry·Howard B Lieberman
Jan 28, 2009·Urologia Internationalis·Xuefeng LiuBin Wu
Mar 10, 2009·Methods : a Companion to Methods in Enzymology·Wenjuan LiaoWei-Guo Zhu
Feb 23, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lluis CatasusJaime Prat
May 21, 2010·Radiation Oncology·Valentina KrstevskaDusko Lukarski
Oct 23, 2010·Molecular Cell·Alberto Ciccia, Stephen J Elledge
Jan 24, 2012·Anti-cancer Agents in Medicinal Chemistry·Cortez-Maya SandraMartinez-Garcia Marcos
Jun 29, 2013·Critical Reviews in Oncology/hematology·Riccardo GiampieriStefano Cascinu
Jul 16, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Julien VignardBernard Salles
May 23, 2014·Current Biology : CB·Michael Schieber, Navdeep S Chandel
Oct 16, 2014·Expert Review of Molecular Diagnostics·Rita M Cabral, Pedro V Baptista
May 9, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Benjamin DemoulinPatrick Dumont
Jan 10, 2016·Journal of the American Chemical Society·Mena S Aioub, Mostafa A El-Sayed

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Citations

Dec 17, 2019·Current Pharmaceutical Design·Weizhen XuGuangwei Wang
Aug 19, 2020·Pharmaceuticals·Clara GerosaDaniela Fanni

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