Phototoxic action of light emitting diode in the in vitro viability of Trichophyton rubrum

Anais Brasileiros De Dermatologia
José Cláudio Faria AmorimMarcos Pinotti

Abstract

Trichophyton rubrum is the most common agent of superficial mycosis of the skin and nails causing long lasting infections and high recurrence rates. Current treatment drawbacks involve topical medications not being able to reach the nail bed at therapeutic concentrations, systemic antifungal drugs failing to eradicate the fungus before the nails are renewed, severe side effects and selection of resistant fungal isolates. Photodynamic therapy (PDT) has been a promising alternative to conventional treatments. This study evaluated the in vitro effectiveness of toluidine blue O (TBO) irradiated by Light emitting diode (LED) in the reduction of T. rubrum viability. The fungal inoculums' was prepared and exposed to different TBO concentrations and energy densities of Light emitting diode for evaluate the T. rubrum sensibility to PDT and production effect fungicidal after photodynamic treatment. In addition, the profiles of the area and volume of the irradiated fungal suspensions were also investigated. A small reduction, in vitro, of fungal cells was observed after exposition to 100 µM toluidine blue O irradiated by 18 J/cm² Light emitting diode. Fungicidal effect occurred after 25 µM toluidine blue O irradiation by Light emitting di...Continue Reading

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Citations

Mar 15, 2014·Anais Brasileiros De Dermatologia·Linton Wallis Figueiredo SouzaAna Cristina de Carvalho Botelho
Nov 6, 2012·Journal of Biophotonics·Leah CroninColin Stack
Sep 1, 2018·Photodermatology, Photoimmunology & Photomedicine·Enrique Alberdi, Clara Gómez
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·Minh LamElma D Baron
Aug 19, 2014·Mycopathologia·Manuel Pablo Paz-CristobalAntonio Rezusta
Apr 21, 2017·Advances in Skin & Wound Care·J Stephen GuffeyPatricia Hensley
Nov 28, 2012·Lasers in Medical Science·Jennifer A LedonKeyvan Nouri
Jan 30, 2014·Anais Brasileiros De Dermatologia·Linton Wallis Figueiredo SouzaAna Cristina de Carvalho Botelho
Mar 26, 2013·Lasers in Medical Science·Leah J CroninColin M Stack
Nov 5, 2020·Photodermatology, Photoimmunology & Photomedicine·Natthamon BowornsathitchaiEinapak Boontaveeyuwat
Mar 9, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Évelin L de OliveiraWilker Caetano

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