Phototransduction Gene Expression and Evolution in Cave and Surface Crayfishes

Integrative and Comparative Biology
David B Stern, Keith A Crandall

Abstract

In the absence of light in caves, animals have repeatedly evolved reduced eyes and visual systems. Whether the underlying genetic components remain intact in blind species remains unanswered across taxa. The freshwater crayfish have evolved to live in caves multiple times throughout their history; therefore, this system provides an opportunity to probe the genetic patterns and processes underlying repeated vision loss. Using transcriptomic data from the eyes of 14 species of cave and surface crayfishes, we identify the expression of 17 genes putatively related to visual phototransduction. We find a similarly complete repertoire of phototransduction gene families expressed in cave and surface species, but that the expression levels of those transcripts are consistently lower in cave species. We find statistical support for episodic positive selection, increased and decreased selection strength in caves, depending on the gene family. Analyses of gene expression evolution suggest convergent and possibly adaptive downregulation of these genes across eye-reduction events. Our results reveal a combination of evolutionary processes acting on the sequences and gene expression levels of vision-related genes underlying the loss of vision...Continue Reading

References

Nov 1, 1991·Trends in Neurosciences·R RanganathanC S Zuker
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Sep 9, 1967·Nature·G Wald
Jun 12, 1997·Nature·K A Crandall, D M Hillis
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Oct 29, 1997·Journal of Molecular Evolution·K A Crandall, T W Cronin
Sep 21, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·H LiR L Cooper
Jan 22, 2004·Bioinformatics·Emmanuel ParadisKorbinian Strimmer
Oct 29, 2004·Bioinformatics·Sergei L Kosakovsky PondSpencer V Muse
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrew Whitehead, Douglas L Crawford
Apr 22, 2006·Molecular Ecology·Andrew Whitehead, Douglas L Crawford
Oct 21, 2006·Molecular Biology and Evolution·Megan L PorterKeith A Crandall
May 12, 2007·Evolution; International Journal of Organic Evolution·Hopi E Hoekstra, Jerry A Coyne
Sep 5, 1969·Science·T L Poulson, W B White
Mar 26, 2008·Nature·UNKNOWN Tribolium Genome Sequencing ConsortiumGregor Bucher
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Trevor Bedford, Daniel L Hartl
Feb 11, 2010·Current Biology : CB·Gordon L FainSimon B Laughlin
Mar 4, 2010·Genome Biology·Mark D Robinson, Alicia Oshlack
May 4, 2010·Nucleic Acids Research·Federico AbascalMaximilian J Telford
Feb 5, 2011·Science·John K ColbourneJeffrey L Boore
Mar 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Meredith E ProtasNipam H Patel
May 17, 2011·Nature Biotechnology·Manfred G GrabherrAviv Regev
Jun 15, 2011·Molecular Biology and Evolution·Sergei L Kosakovsky PondKonrad Scheffler
Oct 14, 2011·The Journal of Experimental Biology·Markus FriedrichStewart B Peck
Oct 21, 2011·Nature·David BrawandHenrik Kaessmann
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Jul 28, 2012·Evolution; International Journal of Organic Evolution·Jeremy M BeaulieuBrian C O'Meara
Oct 13, 2012·Bioinformatics·Limin FuWeizhong Li
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Mar 7, 2013·Evolution; International Journal of Organic Evolution·Matthew L NiemillerThomas J Near
Apr 25, 2013·Molecular Biology and Evolution·Fanwei MengJohn H Postlethwait
Sep 12, 2014·Systematic Biology·Wayne P Maddison, Richard G FitzJohn
Oct 21, 2014·Nature Communications·Suzanne E McGaughWesley C Warren
Oct 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·M Sabrina PankeyTodd H Oakley
Dec 6, 2014·Gene·Chiara ManfrinAlberto Pallavicini
Dec 30, 2014·Molecular Biology and Evolution·Joel O WertheimKonrad Scheffler

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Citations

Sep 22, 2018·Integrative and Comparative Biology·Megan L Porter, Lauren Sumner-Rooney
Jul 28, 2020·Evolution; International Journal of Organic Evolution·Jorge Alves AudinoJosé Eduardo Amoroso Rodriguez Marian
May 23, 2018·Molecular Biology and Evolution·David B Stern, Keith A Crandall
Feb 11, 2021·Communications Biology·Yash SondhiAkito Y Kawahara
May 12, 2021·BMC Ecology and Evolution·Polina DrozdovaMaxim Timofeyev

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