Phrenic and hypoglossal nerve activity during respiratory response to hypoxia in 6-OHDA unilateral model of Parkinson's disease

Life Sciences
Kryspin AndrzejewskiKatarzyna Kaczyńska

Abstract

Parkinson's disease (PD) patients apart from motor dysfunctions exhibit respiratory disturbances. Their mechanism is still unknown and requires investigation. Our research was designed to examine the activity of phrenic (PHR) and hypoglossal (HG) nerves activity during a hypoxic respiratory response in the 6-hydroxydopamine (6-OHDA) model of PD. Male adult Wistar rats were injected unilaterally with 6-OHDA (20μg) or the vehicle into the right medial forebrain bundle (MFB). Two weeks after the surgery the activity of the phrenic and hypoglossal nerve was registered in anesthetized, vagotomized, paralyzed, and mechanically ventilated rats under normoxic and hypoxic conditions. Lesion effectiveness was confirmed by the cylinder test, performed before the MFB injection and 14days after, before the respiratory experiment. 6-OHDA lesioned animals showed a significant increase in normoxic inspiratory time. Expiratory time and total time of the respiratory cycle were prolonged in PD rats after hypoxia. The amplitude of the PHR activity and its minute activity were increased in comparison to the sham group at recovery time and during 30s of hypoxia. The amplitude of the HG activity was increased in response to hypoxia in 6-OHDA lesioned...Continue Reading

Citations

Jan 17, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Srimathy VijayanFrank L Mastaglia
Jan 11, 2019·Physiological Research·K AndrzejewskiK Kaczyńska
Aug 28, 2020·Brain Sciences·Patrick S HosfordShahriar SheikhBahaei
Mar 13, 2020·The Journal of Physiological Sciences : JPS·Kryspin AndrzejewskiKatarzyna Kaczyńska
Feb 18, 2020·Journal of Parkinson's Disease·Rebecca A JohnsonMichelle R Ciucci

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