Phrenic nerve stimulation for the treatment of central sleep apnea

JACC. Heart Failure
William T Abrahamremedē Pilot Study Investigators

Abstract

The aim of this study was to evaluate chronic, transvenous, unilateral phrenic nerve stimulation to treat central sleep apnea (CSA) in a prospective, multicenter, nonrandomized study. CSA occurs predominantly in patients with heart failure and increases the risk for morbidity and mortality. Established therapies for CSA are lacking, and those available are limited by poor patient adherence. Fifty-seven patients with CSA underwent baseline polysomnography followed by transvenous phrenic nerve stimulation system implantation and follow-up. Feasibility was assessed by implantation success rate and therapy delivery. Safety was evaluated by monitoring of device- and procedure-related adverse events. Efficacy was evaluated by changes in the apnea-hypopnea index at 3 months. Quality of life at 6 months was evaluated using a sleepiness questionnaire, patient global assessment, and, in patients with heart failure at baseline, the Minnesota Living With Heart Failure Questionnaire. The study met its primary end point, demonstrating a 55% reduction in apnea-hypopnea index from baseline to 3 months (49.5 ± 14.6 episodes/h vs. 22.4 ± 13.6 episodes/h of sleep; p < 0.0001; 95% confidence interval for change: -32.3 to -21.9). Central apnea inde...Continue Reading

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References

Dec 1, 1985·Neurosurgery·W W Glenn, M L Phelps
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·M T NaughtonT D Bradley
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·P J Hanly, N S Zuberi-Khokhar
Dec 1, 1996·The American Journal of Cardiology·S AndreasH Kreuzer
Nov 12, 2005·The New England Journal of Medicine·T Douglas BradleyUNKNOWN CANPAP Investigators
Jun 15, 2007·JAMA : the Journal of the American Medical Association·Finlay A McAlisterBrian H Rowe
Feb 6, 2008·Proceedings of the American Thoracic Society·Terri E Weaver, Ronald R Grunstein
Jan 21, 2010·Physiological Reviews·Jerome A DempseyChristopher P O'Donnell
Oct 22, 2010·European Journal of Heart Failure·Clemens JilekMichael Arzt
Dec 27, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Noriaki Takama, Masahiko Kurabayashi

❮ Previous
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Citations

Feb 13, 2016·European Journal of Heart Failure·Simon G Pearse, Martin R Cowie
Aug 11, 2015·Chest·Reena Mehra, Daniel J Gottlieb
Apr 9, 2016·Indian Heart Journal·Stefan D AnkerRobin Germany
Jan 10, 2016·JACC. Heart Failure·Martin R Cowie
Dec 3, 2015·Current Opinion in Critical Care·Basil J Petrof, Sabah N Hussain
Dec 10, 2015·European Journal of Heart Failure·Haye H van der WalPeter van der Meer
Mar 12, 2016·International Journal of Cardiology·Susan Joseph, Maria Rosa Costanzo
Mar 14, 2016·International Journal of Cardiology·Andrew J Stewart Coats, Louise G Shewan
Sep 28, 2015·Journal of Cardiac Failure·Michele EmdinAlberto Giannoni
Aug 12, 2015·Annals of Physical and Rehabilitation Medicine·J Gonzalez-BermejoC Morélot-Panzini
Sep 2, 2015·The New England Journal of Medicine·Ulysses J Magalang, Allan I Pack
Apr 24, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Dominik LinzOlaf Oldenburg
May 14, 2016·Nature Reviews. Cardiology·Gianfranco ParatiUNKNOWN Italian Society of Cardiology (SIC) Working Group on Heart Failure members
May 29, 2016·Sleep Medicine Clinics·Shahrokh JavaheriJohn J Greer
May 29, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alexandre GuinandHaran Burri
May 29, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Tarek Bekfani, William T Abraham
May 7, 2016·Expert Review of Cardiovascular Therapy·Lida Pieretta PapavasileiouMassimo Santini
Sep 7, 2016·Lancet·Maria Rosa CostanzoUNKNOWN remedé System Pivotal Trial Study Group
Nov 5, 2016·European Journal of Heart Failure·Martin R Cowie
Oct 21, 2016·Current Heart Failure Reports·Martin R Cowie
Nov 1, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeremy E OrrScott A Sands
Jan 6, 2017·Pacing and Clinical Electrophysiology : PACE·Lukas R C DekkerLilian Kornet
Feb 17, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·J Howard Jaster
Feb 18, 2017·Pacing and Clinical Electrophysiology : PACE·Henrik FoxKlaus-Jürgen Gutleben
Jul 26, 2017·Critical Pathways in Cardiology·Emad F AzizEyal Herzog
Apr 5, 2018·Current Heart Failure Reports·Connor P OatesStephen S Gottlieb
Mar 11, 2018·Heart Failure Reviews·Maxwell Eyram AfariLana Tsao
Mar 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Jonathan C JunAlan R Schwartz
Aug 5, 2017·Expert Review of Cardiovascular Therapy·Chiara BorrelliAlberto Giannoni
Jul 18, 2019·Current Opinion in Pulmonary Medicine·Winfried Randerath, Simon Herkenrath
Oct 4, 2019·Journal of Neural Engineering·Ryan G L KohJosé Zariffa
Aug 26, 2020·Journal of Cardiovascular Electrophysiology·Klaus-Jürgen GutlebenHenrik Fox
Sep 1, 2017·Annals of the American Thoracic Society·Shazia M JamilTisha Wang
Aug 16, 2017·Current Heart Failure Reports·Sushma M Dharia, Lee K Brown
Oct 12, 2018·Herzschrittmachertherapie & Elektrophysiologie·Christoph StellbrinkDennis Lawin
Jul 28, 2019·Intensive Care Medicine Experimental·Oscar PeñuelasJosé Ángel Lorente
Jul 10, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jonathan StermanMeir H Scheinfeld
May 24, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Ghulam MurtazaDhanunjaya Lakkireddy
Jul 24, 2020·Sleep Medicine Research·Younghoon KwonChi-Hang Lee
Aug 19, 2017·Physiological Measurement·Mehdi ShokoueinejadJohn Webster
Feb 2, 2018·Annals of the American Thoracic Society·Najib T AyasUNKNOWN ATS Assembly on Sleep and Respiratory Neurobiology
Mar 24, 2018·Current Treatment Options in Cardiovascular Medicine·MuChun Tsai, Rami Khayat

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