Phthalates and neurotoxic effects on hippocampal network plasticity

Neurotoxicology
M R Holahan, Catherine A Smith

Abstract

Phthalates are synthetically derived chemicals used as plasticizers in a variety of common household products. They are not chemically bound to plastic polymers and over time, easily migrate out of these products and into the environment. Experimental investigations evaluating the biological impact of phthalate exposure on developing organisms are critical given that estimates of phthalate exposure are considerably higher in infants and children compared to adults. Extensive growth and re-organization of neurocircuitry occurs during development leaving the brain highly susceptible to environmental insults. This review summarizes the effects of phthalate exposure on brain structure and function with particular emphasis on developmental aspects of hippocampal structural and functional plasticity. In general, it appears that widespread disruptions in hippocampal functional and structural plasticity occur following developmental (pre-, peri- and post-natal) exposure to phthalates. Whether these changes occur as a direct neurotoxic effect of phthalates or an indirect effect through disruption of endogenous endocrine functions is not fully understood. Comprehensive investigations that simultaneously assess the neurodevelopmental, neu...Continue Reading

References

Nov 8, 1985·The Journal of Comparative Neurology·F B Gaarskjaer
Jan 1, 1973·Environmental Health Perspectives·P R Graham
Aug 1, 1973·Experimental Neurology·W T Greenough, F R Volkmar
Jul 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·H F HarlowM K Harlow
Feb 1, 1970·The Journal of Physiology·P B Dews, T N Wiesel
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·M B MoserR G Morris
Jun 1, 1995·Trends in Neurosciences·F A Edwards
Oct 1, 1994·Toxicology and Applied Pharmacology·B J DavisJ J Heindel
Jan 1, 1993·Brain Research. Brain Research Reviews·P A Colley, A Routtenberg
Dec 1, 1996·Journal of Neurocytology·M E CalhounP R Mouton
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
Apr 16, 1998·Environmental Health Perspectives·T M CrispY M Patel
Apr 22, 1999·Food Additives and Contaminants·I SteinerJ Washüttl
Jan 21, 2000·Hippocampus·V Ramírez-AmayaF Bermúdez-Rattoni
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Jun 28, 2000·Neuroscience·D A HenzeG Barrionuevo
Oct 24, 2000·Toxicology and Applied Pharmacology·K TullyS N Treistman
Oct 29, 2000·Science·A Matus
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L G ParksL E Gray
Jun 8, 2001·Trends in Cognitive Sciences·L Nadel, M Moscovitch
Sep 22, 2001·Biology of Reproduction·B T AkingbemiM P Hardy
Oct 20, 2001·Genes & Development·Y N Jan, L Y Jan
Jun 4, 2002·Food Additives and Contaminants·K Bouma, D J Schakel
Apr 23, 2003·Molecular and Cellular Endocrinology·Tara Lovekamp-SwanBarbara J Davis
Jun 24, 2003·Neuron·David B Kantor, Alex L Kolodkin
Jul 5, 2003·Environmental Health Perspectives·Dana B BarrAntonia M Calafat
Mar 1, 1954·Canadian Journal of Psychology·W R THOMPSON, W HERON
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Nov 5, 2003·Environmental Health Perspectives·Giuseppe LatiniPietro Mazzeo
Jan 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Benson T AkingbemiMatthew P Hardy
Feb 7, 2004·International Journal of Hygiene and Environmental Health·Holger M KochJürgen Angerer
Mar 11, 2004·Indoor Air·A AfshariV Hansen

❮ Previous
Next ❯

Citations

Oct 31, 2015·International Journal of Environmental Research and Public Health·Catherine A SmithJeffrey C Smith
Sep 5, 2019·Journal of Exposure Science & Environmental Epidemiology·Yanelli Rodríguez-CarmonaDeborah Watkins
Jul 1, 2017·Environmental Science and Pollution Research International·Bruna de Oliveira MendesGuilherme Malafaia
Mar 16, 2019·Environmental Health Perspectives·Julia R Barrett
Jan 19, 2021·Pharmacological Reports : PR·Henrieta HlisníkováAlexander Sirotkin
Jul 18, 2020·Environment International·Sharon DanielPam Factor-Litvak
Nov 8, 2020·International Journal of Environmental Research and Public Health·Libni A Torres-OlascoagaMarcela Tamayo-Ortiz
Feb 19, 2021·American Journal of Public Health·Stephanie M EngelRobin M Whyatt
May 1, 2021·International Journal of Molecular Sciences·Laura LucaccioniLorenzo Iughetti
May 10, 2021·The Science of the Total Environment·Wei-Hsiang ChangHsiu-Ling Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Clinical and Experimental Pharmacology & Physiology
Kent E Pinkerton, Jesse P Joad
Environmental Health Perspectives
Nikki Gillum PosnackNarine Sarvazyan
International Journal of Hygiene and Environmental Health
Ursel HeudorfJürgen Angerer
© 2022 Meta ULC. All rights reserved