PMID: 3770961Jan 1, 1986Paper

Phthalic acid excretion as an indicator of exposure to phthalic anhydride in the work atmosphere

International Archives of Occupational and Environmental Health
P Pfäffli

Abstract

The concentration of phthalic acid was determined in the urine of nine subjects occupationally exposed to phthalic anhydride. For the determination, the urine samples were acidified, extracted with dimethyl ether, esterified with boron trifluoride/methanol and measured by electron capture gas chromatography. Environmental air samples were collected in Tenax tubes, eluted with methyl-t-butyl ether and assayed by electron capture gas chromatography. Significant correlations were found between the concentration in urine samples (range: 0.3-14.0 mumol/mmol creatinine), collected at different times of the day, and the time-weighed average atmospheric concentrations (range: 0.03-10.5 mg/m3). No conjugation of phthalic acid in the urine was observed. The detection limit for urine samples (10 ml) was 0.05 mumol/l) and that for air samples 0.4 microgram/m3. The method has potential for biological monitoring of workers exposed to phthalic anhydride. It was found that at atmospheric anhydride concentrations of about 30% of the hygienic reference value (6 mg/m3), which is applied in many market economies, a body-burden was caused which was not eliminated overnight.

References

Jul 1, 1978·Toxicology and Applied Pharmacology·J A ThomasL Martis
Jan 1, 1977·Clinical Allergy·E H ChesterS Greenstein
Feb 21, 1977·Journal of Chromatography·C F Poole, D G Wibberley
Jun 1, 1973·Environmental Health Perspectives·J Autian
May 1, 1970·Toxicology and Applied Pharmacology·O M Bakke, R R Scheline
Feb 1, 1984·Analytical Chemistry·P W AlbroJ L Schroeder
May 1, 1980·Clinical Allergy·G PauliJ C Limasset

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Citations

Jan 1, 1991·International Archives of Occupational and Environmental Health·B JönssonG Skarping
Jan 29, 2002·International Immunopharmacology·Xing Dong ZhangDaniel M Lewis
Dec 1, 2011·Toxicological Research·Du Yeon BangByung-Mu Lee
Dec 16, 2011·BMC Public Health·Lubomir StrakaJan Danko
Feb 22, 2011·Analytical and Bioanalytical Chemistry·Aurélie BerthetMichèle Bouchard
Oct 4, 2008·Chemical Research in Toxicology·Marina C JeppssonChristian H Lindh

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