Phthalocyanine photodynamic therapy: new strategy for closure of choroidal neovascularization

Lasers in Surgery and Medicine
G H KlimanW A Gregory

Abstract

Chloro-aluminum sulfonated phthalocyanine (CASPc) is a photo-chemically active dye employed in photodynamic therapy (PDT). CASPc is a potent generator of singlet oxygen when irradiated with 675 nm light and is also capable of fluorescence, allowing visualization of the dye in tissues. We devised an angiography system using CASPc fluorescence to determine its localization in experimental choroidal neovascularization in monkeys and then investigated the ability of CASPc to produce photochemical closure of neovascularization upon irradiation with 675nm laser light. Fluorescent imaging indicated that CASPc localized angiographically in areas of neovascularization for at least 24 hours. Irradiation with 675 nm laser light 5-30 minutes after CASPc injection produced complete closure of choroidal neovascularization with minimal damage to overlying retina. We conclude that CASPc localizes in neovascular choroidal vessels and that CASPc photodynamic therapy can produce closure of these choroidal vessels.

References

Nov 1, 1987·Photochemistry and Photobiology·J F Evensen, J Moan
Aug 1, 1987·Archives of Ophthalmology·S K NandaT McAdoo
Nov 1, 1982·Archives of Ophthalmology·S J Ryan
Jan 1, 1983·Transactions of the New Orleans Academy of Ophthalmology·S J Ryan
Feb 1, 1984·American Journal of Ophthalmology·J W Berkow
Aug 1, 1984·Archives of Ophthalmology·A J PackerS S Hayreh
Jan 1, 1994·Lasers in Surgery and Medicine·G H KlimanW A Gregory

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Citations

Jul 13, 2002·Lasers in Surgery and Medicine·Akira Obana, Yuko Gohto
Jan 1, 1995·Lasers in Surgery and Medicine·J M Krauss, C A Puliafito
Oct 31, 1998·Harvard Women's Health Watch
Jan 27, 2000·Ophthalmology·G A PeymanD M Moshfeghi
Oct 24, 2001·Advanced Drug Delivery Reviews·R Z Renno, J W Miller
Sep 7, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yan HuangMaosong Xie
Aug 13, 2002·Retina·Kathryn W WoodburnMark S Blumenkranz
Aug 1, 1995·The British Journal of Ophthalmology·S Asrani, R Zeimer
Mar 9, 2002·Photochemistry and Photobiology·Hirokazu NishiwakiRhonda Grebe
Apr 22, 2015·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Igor Kozak, Jeffrey K Luttrull
Mar 27, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alberto L ArvayoMarc E Levenston
May 3, 2000·Seminars in Ophthalmology·M IpE Reichel
Jan 29, 2020·Archives of Pharmacal Research·Jiyoung KimKun Na
Oct 8, 1998·Survey of Ophthalmology·T A CiullaA Harris

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