Phtytochemical Studies and Quantitative HPLC Analysis of Rosmarinic Acid and Luteolin 5-O-β-D-Glucopyranoside on Thymus praecox subsp. grossheimii var. grossheimii

Chemical & Pharmaceutical Bulletin
Handan Gokben SevindikHayri Duman

Abstract

Thymus praecox ssp. grossheimii (RONNIGER) JALAS var. grossheimii (Lamiaceae) is used as an herbal tea for cold, stomachache, cough, and infections in Turkey. There are no phytochemical studies on this species. We performed phytochemical studies and quantitative analysis of rosmarinic acid and luteolin 5-O-β-D-glucopyranoside in the methanol extract of the plant. Several chromatographic methods were used for the isolation of major compounds. HPLC methods were applied for quantitative analysis of rosmarinic acid and luteolin 5-O-β-D-glucopyranoside in the methanol extract. In this study, ursolic acid (1), oleanolic acid (2), methyl rosmarinate (3), ethyl rosmarinate (4), rosmarinic acid (5), luteolin 5-O-β-D-glucopyranoside (6), and thymoquinol 2,5-O-β-diglucopyranoside (7) were isolated from the aerial parts of the plant. The relative contents of rosmarinic acid and luteolin 5-O-β-D-glucopyranoside in the extract were 15.2 and 57.8 mg/g of dry weight, respectively. Compounds isolated from this plant and the contents of rosmarinic acid and luteolin 5-O-β-D-glucopyranoside provided reasonable evidence for the traditional usages of this plant.

References

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Mar 17, 2004·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Ayse Dilek AzazKemal Husnu Can Baser
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Citations

Mar 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Silvia RevoltellaHermann Stuppner
Jun 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea F AfonsoSusana M Cardoso
Jul 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rita de Cássia Lemos LimaDan Staerk
Apr 27, 2019·Food Science & Nutrition·Natsuko KagawaMitsumasa Hanaoka
Aug 28, 2019·Marine Drugs·Iván Cheng-SánchezAna R Quesada

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