PMID: 15242017Jul 10, 2004Paper

Phycocyanin enhances secretary IgA antibody response and suppresses allergic IgE antibody response in mice immunized with antigen-entrapped biodegradable microparticles

Journal of Nutritional Science and Vitaminology
Chinami Nemoto-KawamuraO Hayashi

Abstract

In the present study, we have investigated the effects of phycocyanin, a biliprotein of Spirulina platensis, on mucosal and systemic immune responses and allergic inflammation in C3H/HeN and BALB/cA mice. To induce the antigen-specific antibodies in the peripheral lymphoid tissues such as Peyer's patches and mesenteric lymph nodes, biodegradable ovalbumin-entrapped poly (DL-lactide-co-glycolide) particles were used as an antigen. Two weeks after the onset of phycocyanin ingestion, mice were immunized with an aqueous ovalbumin (OVA) solution. Starting at one week after the primary immunization, the mice were subjected to oral immunization with the biodegradable OVA microparticles twice a week. IgA, IgE and IgG1 antibodies were determined by ELISA. The OVA microparticles of 4-microm diameter successfully induced antigen-specific antibodies. In the mice that received phycocyanin treatment for 6 wk, a marked increase in the antigen-specific, as well as the total, IgA antibody level was observed in the Peyer's patches, mesenteric lymph nodes and intestinal mucosa as well as in the spleen cells. Both antigen-specific IgG1 and IgE antibody levels in the serum were suppressed by ingestion of phycocyanin for 8 wk. However, inflammation ...Continue Reading

Citations

Feb 23, 2012·Journal of Biotechnology·Miroslav GantarJaroslava Miksovska
Apr 1, 2008·Journal of Phycology·Miroslav Gantar, Zorica Svirčev
Aug 10, 2013·Journal of Dietary Supplements·Wan-Loy ChuAmmu Kutty Radhakrishnan
Jun 14, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Qian LiuYu Cai
Jun 15, 2021·Frontiers in Nutrition·Ebenezer SatyarajPeichuan Sun
Sep 9, 2021·Critical Reviews in Food Science and Nutrition·Tian YangZhongfu Wang

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