Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2

Food & Function
Yingnv GaoYu Ou

Abstract

Methylglyoxal (MG) is a reactive dicarbonyl compound, whose abnormal accumulation in diabetic patients exerts deleterious effects on cells and tissues. The β-cell is the main target cell of Type 2 diabetes, and its insulin secretion injury and cell apoptosis can be due to mitochondrial dysfunction. Previous studies have demonstrated MG induced β-cell apoptosis. However, little is known about the effect of MG on β-cell mitochondrial dysfunction. Phycocyanin (PC) has been demonstrated to possess various biological activities including the effects on diabetic models in vivo. The aim of this study was to determine the protective effect of PC against methylglyoxal (MG)-induced dysfunction in pancreatic β-cell INS-1 and also the mechanism. We demonstrated that MG induced mitochondrial dysfunction by the decline in ATP levels, and the increase of the level of intracellular reactive oxygen species (ROS). Furthermore, MG released cytochrome c and apoptosis-inducing factor (AIF) from the mitochondrion, induced changes in the expression of Bcl-2 family members, activated caspases and increased PARP cleavage. Interestingly, PC activated nuclear erythroid-related factor 2 (Nrf2), and Nrf2 activation as well as antioxidant enzymes HO-1 and g...Continue Reading

References

May 17, 2000·The Journal of Pharmacy and Pharmacology·C Romay, R González
Aug 17, 2000·Biochemical and Biophysical Research Communications·V B Bhat, K M Madyastha
Oct 29, 2000·The Journal of Biological Chemistry·E B AffarG G Poirier
May 29, 2003·Current Protein & Peptide Science·Ch RomayV Rimbau
Dec 4, 2003·Current Opinion in Cell Biology·Kelly M Boatright, Guy S Salvesen
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
Jun 21, 2005·Annals of the New York Academy of Sciences·Wen-Hsiung ChanYan-Der Hsuuw
Sep 30, 2005·Journal of Agricultural and Food Chemistry·George HsiaoJoen-Rong Sheu
Dec 1, 2005·Biotechnology and Applied Biochemistry·Bing LiXian-Ming Chu
Dec 16, 2005·Molecular and Cellular Biology·Akira KobayashiMasayuki Yamamoto
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tianzheng YuYisang Yoon
Feb 24, 2006·Toxicology and Applied Pharmacology·Anabela P Rolo, Carlos M Palmeira
Aug 22, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H K MadhyasthaM Maruyama
Nov 4, 2006·Biological Chemistry·Kit I TongMasayuki Yamamoto
Jun 28, 2008·Stroke; a Journal of Cerebral Circulation·Bianzhi XingSuming Zhang
Jun 9, 2009·Toxicology and Applied Pharmacology·Jingbo PiMelvin E Andersen
Apr 13, 2012·EMBO Molecular Medicine·Luigi LeanzaIldikò Szabò
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Weijing CaiHelen Vlassara
Oct 16, 2012·Circulation Research·Lorenzo GalluzziGuido Kroemer
Nov 6, 2012·Environmental Toxicology and Pharmacology·Yu OuXiaodong Cheng
Feb 2, 2013·Pharmaceutical Biology·Yu OuXiaodong Cheng
Feb 5, 2013·Metabolic Brain Disease·Luana HeimfarthRegina Pessoa-Pureur
Feb 22, 2013·American Journal of Physiology. Cell Physiology·Yun-Min ZhengYong-Xiao Wang
Dec 10, 2013·Free Radical Biology & Medicine·Pamela Boon Li PunMichael P Murphy
Apr 4, 2014·Journal of Agricultural and Food Chemistry·Ramar ThangamJayanthi Sivaraman
May 28, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Manpreet Kaur Saini, Sankar Nath Sanyal
Dec 1, 2015·International Journal of Biological Macromolecules·Yingnv GaoYu Ou

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Citations

Feb 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ki Mo KimSungwook Chae
Nov 30, 2019·Current Drug Metabolism·Saira M BannuMadhava C Reddy
Feb 10, 2017·Oxidative Medicine and Cellular Longevity·Alberto FinamoreIlaria Peluso
Nov 28, 2020·Trends in Endocrinology and Metabolism : TEM·Sharon Baumel-AlterzonDonald K Scott
May 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dan TangHong Nie
Aug 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qi LiuSong Qin
Sep 27, 2018·Journal of Agricultural and Food Chemistry·Shuai HaoChengtao Wang
Mar 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aramsri MeepromSirichai Adisakwattana
Aug 17, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tom GurneyOwen Spendiff

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