Phyllodes tumours of the breast: a consensus review

Histopathology
Benjamin Y TanPuay Hoon Tan

Abstract

Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational appro...Continue Reading

References

May 1, 1976·Postgraduate Medicine·D M Nigro, C H Organ
Apr 1, 1971·Annals of Surgery·T L WestO T Clagett
Oct 20, 1998·The American Journal of Surgical Pathology·J KrachtG Bussolati
Nov 20, 1998·Breast Cancer Research and Treatment·M KasamiD L Page
May 14, 1999·Archives of Surgery·A A MangiW W Souba
Mar 7, 2000·The American Journal of Pathology·E J SawyerI P Tomlinson
Oct 3, 2000·Cancer·A W ChaneyK K Hunt
Jun 28, 1996·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S NoguchiA Wada
Nov 30, 2000·Surgical Oncology·D A August, T Kearney
Dec 6, 2000·The Journal of Surgical Research·C M ChenH J Harn
Dec 12, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I KapirisG P Gui
Feb 15, 2002·The Breast Journal·M PandeyK M Nair
Mar 29, 2002·The Journal of Pathology·Elinor J SawyerIan P M Tomlinson
Sep 5, 2002·The Journal of Pathology·Arno KuijperPaul J van Diest
Oct 19, 2004·The American Journal of Surgical Pathology·Meryem M Koker, Celina G Kleer
Mar 4, 2005·American Journal of Clinical Pathology·Puay-Hoon TanBoon-Huat Bay
Aug 25, 2005·Journal of Surgical Oncology·Wei-Hong ChenTsang-Pai Liu
Sep 24, 2005·Annals of the Royal College of Surgeons of England·W SotheranP M Perry
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Puay-Hoon TanBoon-Huat Bay
Feb 18, 2006·Pathology·Gary M TseAnthony W I Lo
Mar 24, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna SapinoGianni Bussolati
May 17, 2006·International Journal of Surgical Pathology·Wen-Chiuan TsaiLai-Fa Sheu
Jul 26, 2006·World Journal of Surgery·Shih-Ping ChengChien-Liang Liu
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marick LaéJérôme Couturier
Mar 8, 2007·Onkologie·Josip FajdićManfred Kaufmann
Sep 18, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Miriam S LenhardIngo Bauerfeind
Oct 13, 2007·International Journal of Radiation Oncology, Biology, Physics·Yazid BelkacémiMahmut Ozsahin

❮ Previous
Next ❯

Citations

Sep 4, 2016·Surgical Oncology Clinics of North America·Katherine Thornton
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Luisella RighiGiorgio Vittorio Scagliotti
Sep 24, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yayoi TakamotoHideyuki Saya
Mar 8, 2017·Molecular Oncology·Felipe C GeyerBritta Weigelt
May 19, 2018·International Journal of Surgical Pathology·Jaehag JungEun-Kyu Kim
Dec 17, 2017·Medicine·Qinqin WangYutao Lei
Oct 18, 2016·Rare Tumors·Charlotte SchillebeeckxMarc Bronckaers
Nov 18, 2017·Journal of Clinical Pathology·Michael CoAva Kwong
Feb 17, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elzbieta SlodkowskaWedad Hanna
Mar 5, 2019·Diagnostic Cytopathology·Joshua J X LiGary M Tse
Mar 21, 2019·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Katrina B MitchellUNKNOWN Academy of Breastfeeding Medicine
Mar 23, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lene Gaarsmand ChristensenMaj-Lis Talman
May 22, 2019·Annals of Surgical Oncology·Joshua LiGary M Tse
Aug 15, 2019·The Journal of Pathology·Nur Diyana Md NasirPuay Hoon Tan
Sep 4, 2019·The Breast Journal·Yasmine PapasImad Hajj
Feb 21, 2019·Annals of Surgical Oncology·Philip M SpanheimerAndrea V Barrio
Feb 25, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Robert S LimJean Seely
Apr 17, 2020·The Breast Journal·Irene ValenteCecilia D'Aloia
Apr 12, 2020·Breast Cancer Research and Treatment·Philou C W NoordmanBart C Vrouenraets
May 21, 2019·Journal of Pediatric Hematology/oncology·Safina HafeezAndrew Ricci
May 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Puay Hoon Tan
Jan 27, 2018·Archives of Pathology & Laboratory Medicine·Laurence M Briski, Julie M Jorns
May 12, 2017·Cancer·Dario CallegaroAlessandro Gronchi
Oct 29, 2017·Pediatric Radiology·Linda M SandersAlison Esteva Sanders
Nov 12, 2017·Virchows Archiv : an International Journal of Pathology·Valerie Cui Yun KohPuay Hoon Tan
Feb 12, 2019·Journal of Toxicologic Pathology·Satomi FunahashiShinya Toyokuni
Apr 9, 2019·Proceedings·Alden P GregstonJohn Pippen
Jan 29, 2020·Annals of Surgical Oncology·Mathias NeronUNKNOWN French Sarcoma Group (GSF-GETO)
Apr 24, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Benjamin Yongcheng TanPuay Hoon Tan
Oct 6, 2020·Indian Journal of Surgical Oncology·Maher H IbreaheemOmnia Talaat
Feb 18, 2017·Breast Cancer Research and Treatment·Sahar NozadJon H Chung
Apr 7, 2017·International Journal of Surgical Pathology·Magnus Hallin, Khin Thway

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.