Phylogenetic analysis of acute hepatitis C virus genotype 4 infections among human immunodeficiency virus-positive men who have sex with men in Germany

Liver International : Official Journal of the International Association for the Study of the Liver
Martin VogelJürgen K Rockstroh

Abstract

An ongoing HCV epidemic currently affects a growing proportion of HIV-positive men who have sex with men (MSM) in Europe. Recently in the North-Rhine region of Germany, we have observed an increase in acute HCV infections of genotype 4 (HCV-4). To characterize the current spread of HCV-4 among German MSM using a molecular epidemiological approach. Patient characteristics and sera were collected for HIV-positive MSM diagnosed with acute HCV-4 infections in the North-Rhine region (n=14), Hamburg (n=14), Frankfurt (n=4) and Berlin (n=4). Part of the HCV NS5B region (436 bp) was amplified, sequenced and compared with HCV-4 sequences from HIV-positive Dutch, English and French MSM (n=50) as well as unrelated HCV risk groups (n=61). NS5B sequences were obtained from 35/36 (97%) of German cases, all of which were HCV subtype 4d (HCV-4d). The phylogenetic analysis of HCV sequences revealed two MSM-specific HCV-4d clusters of 71 and 12 sequences. All except one of the German MSM belonged to a large MSM-specific HCV cluster containing MSM from all four different European countries. None of the HCV-4 strains circulating among injecting drug users or in HCV-4 endemic areas were part of the MSM-specific clusters. HCV rapidly spreads among E...Continue Reading

References

Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A Terrault
Apr 12, 2003·Sexually Transmitted Infections·B MarincovichC Rodríguez
Oct 8, 2003·Systematic Biology·Stéphane Guindon, Olivier Gascuel
Dec 16, 2004·JAMA : the Journal of the American Medical Association·Fabrice CarratUNKNOWN ANRS HCO2 RIBAVIC Study Team
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andri RauchUNKNOWN Swiss HIV Cohort Study
Jun 16, 2007·The Journal of Infectious Diseases·Thijs J W van de LaarRoel A Coutinho
Jul 17, 2008·The Journal of Infectious Diseases·Daniel S FiererAndrea D Branch
Jun 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin VogelUNKNOWN Hep-Net
Oct 3, 2009·Journal of Gastroenterology and Hepatology·Heather F GiddingMatthew G Law

❮ Previous
Next ❯

Citations

Sep 4, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Tzu TsengChien-Ching Hung
Nov 28, 2013·Infectious Disease Clinics of North America·Linda Gorgos
Oct 23, 2012·Infectious Disease Clinics of North America·Christoph BoeseckeJürgen Kurt Rockstroh
Jul 31, 2012·Antiviral Research·Lisa SandmannSandra Ciesek
Feb 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Natasha K MartinPeter Vickerman
Jul 17, 2012·Journal of Hepatology·Behzad HajarizadehGregory J Dore
Jun 9, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Denise P C ChanChien-Ching Hung
Dec 19, 2017·BMC Medicine·Victor VirlogeuxUNKNOWN Dat’AIDS Study Group
Mar 1, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David C BoettigerGail V Matthews
Feb 28, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christophe RamièreUNKNOWN Lyon Acute Hepatitis Study Group
May 22, 2019·Journal of the International AIDS Society·Sophia E SchroederMark Stoové
Apr 27, 2011·Current Opinion in HIV and AIDS·Christoph Boesecke, Jürgen K Rockstroh
Dec 18, 2012·Current Opinion in Infectious Diseases·Daniel BradshawMark Danta
Oct 18, 2011·Current Opinion in HIV and AIDS·Christoph Boesecke, Martin Vogel
Sep 25, 2020·Journal of the International AIDS Society·Chin Pok ChanShui Shan Lee
Oct 21, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luisa Salazar-VizcayaUNKNOWN Swiss HIV Cohort Study
Jun 5, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Clara SánchezVincent Soriano
Feb 22, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Dana BusschotsGeert Robaeys
Feb 12, 2019·International Journal of Antimicrobial Agents·Eve TodescoMarc-Antoine Valantin
Feb 9, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B VisseauxJ Ghosn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.