Phylogenetic analysis of clinical herpes simplex virus type 1 isolates identified three genetic groups and recombinant viruses

Journal of Virology
P NorbergJan-Ake Liljeqvist

Abstract

Herpes simplex virus type 1 (HSV-1) is a ubiquitous human pathogen which establishes lifelong infections. In the present study, we determined the sequence diversity of the complete genes coding for glycoproteins G (gG), I (gI), and E (gE), comprising 2.3% of the HSV-1 genome and located within the unique short (US) region, for 28 clinical HSV-1 isolates inducing oral lesions, genital lesions, or encephalitis. Laboratory strains F and KOS321 were sequenced in parallel. Phylogenetic analysis, including analysis of laboratory strain 17 (GenBank), revealed that the sequences were separated into three genetic groups. The identification of different genogroups facilitated the detection of recombinant viruses by using specific nucleotide substitutions as recombination markers. Seven of the isolates and strain 17 displayed sequences consistent with intergenic recombination, and at least four isolates were intragenic recombinants. The observed frequency of recombination based on an analysis of a short stretch of the US region suggests that most full-length HSV-1 genomes consist of a mosaic of segments from different genetic groups. Polymorphic tandem repeat regions, consisting of two to eight blocks of 21 nucleotides in the gI gene and ...Continue Reading

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Citations

Nov 22, 2008·Virus Genes·G P Martín OcamposC M Galosi
Jan 18, 2008·The Journal of Infectious Diseases·David M Koelle, Tracy L Bergemann
Jul 11, 2006·Journal of Clinical Microbiology·Emily Toth MartinAnna Wald
Oct 13, 2006·Journal of Clinical Microbiology·Peter NorbergJan-Ake Liljeqvist
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