Nov 8, 2007

Phylogenetic analysis of the chromate ion transporter (CHR) superfamily

The FEBS Journal
César Díaz-PérezHéctor Riveros-Rosas

Abstract

ChrA is a membrane protein that confers resistance to the toxic ion chromate through the energy-dependent chromate efflux from the cytoplasm. In the protein databases, ChrA is a member of the chromate ion transporter (CHR) superfamily, composed of at least several dozens of members, distributed in the three domains of life. The aim of this work was to perform a phylogenetic analysis of the CHR superfamily. An exhaustive search for ChrA homologous proteins was carried out at the National Center for Biotechnology Information database. One hundred and thirty-five sequences were identified as members of the CHR superfamily [77 long-chain sequences, or bidomains (LCHR), and 58 short-chain sequences, or monodomains (SCHR)], organized mainly as tandem pairs of genes whose resultant proteins probably possess oppositely oriented membrane topology. LCHR sequences were split into amino and carboxyl domains, and the resultant domains were aligned with the SCHR proteins. A phylogenetic tree was reconstructed using four different methods, obtaining similar results. The domains were grouped into three clusters: the SCHR proteins cluster, the amino domain cluster of LCHR proteins and the carboxyl domain cluster of LCHR proteins. These results,...Continue Reading

  • References29
  • Citations24

References

Mentioned in this Paper

Bacterial Proteins
Genome
Menkes Kinky Hair Syndrome
Genes, Reiterated
Tertiary Protein Structure
Homologous Sequences, Amino Acid
Chromate Transport
Phylogeny
Genomics
Pseudomonas aeruginosa

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