PMID: 9545468Jun 6, 1998Paper

Phylogenetic and functional classification of mitogen- and stress-activated protein kinases

Journal of Molecular Evolution
D Kültz

Abstract

All currently sequenced stress-activated protein kinases (SAPKs), extracellular signal-regulated kinases (ERKs), and other mitogen-activated protein kinases (MAPKs) were analyzed by sequence alignment, phylogenetic tree construction, and three-dimensional structure modeling in order to classify members of the MAPK family. Based on this analysis the MAPK family was divided into three subgroups (SAPKs, ERKs, and MAPK3) that consist of at least nine subfamilies. Members of a given subfamily were exclusively from animals, plants, or yeast/fungi. A single signature sequence, [LIVM][TS]XX[LIVM]XT[RK][WY]YRXPX[LIVM] [LIVM], was identified that is characteristic for all MAPKs and sufficient to distinguish MAPKs from other members of the protein kinase superfamily. This signature sequence contains the phosphorylation site and is located on loop 12 of the three-dimensional structure of MAPKs. I also identified signature sequences that are characteristic for each of the nine subfamilies of MAPKs. By modeling the three-dimensional structure of three proteins for each MAPK subfamily based on the resolved atomic structures of rat ERK2 and murine p38, it is demonstrated that amino acids conserved in all MAPKs are located primarily in the cent...Continue Reading

Citations

Dec 3, 1999·Biochemical and Biophysical Research Communications·R J Gum, P R Young
Mar 29, 2001·Fungal Genetics and Biology : FG & B·J R Xu
Apr 1, 2008·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Anil K SinghSneh L Singla-Pareek
Apr 6, 2004·Plant Physiology and Biochemistry : PPB·Ignacio Islas-FloresS M Hernández-Sotomayor
Nov 26, 2003·International Journal for Parasitology·Martin WieseIris Görcke
Jul 4, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·D Kültz, K Avila
Oct 13, 2001·Current Opinion in Plant Biology·G TenaJ Sheen
Jun 8, 2013·Cell Death & Disease·T ArsenijevicC Delporte
Jan 3, 2001·The Plant Journal : for Cell and Molecular Biology·K Mockaitis, S H Howell
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fabien JammesJune M Kwak
Jul 13, 2006·Eukaryotic Cell·Debora Domenicali PfisterErik Vassella
Feb 16, 2005·Annual Review of Physiology·Dietmar Kültz
Jun 4, 2011·Journal of Signal Transduction·Michael J BrumlikTyler J Curiel
Jul 17, 2010·Future Microbiology·Inês CorreiaJesús Pla
Mar 4, 2014·Plant Physiology and Biochemistry : PPB·Congjin WeiAichun Zhao
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yan JinEviatar Nevo
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Artemio Mendoza-MendozaAlfredo Herrera-Estrella
Mar 22, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·C E HerbisonP Price
Feb 14, 2016·Journal of Insect Physiology·Craig A L RiedlMarla B Sokolowski
May 18, 2004·The Journal of Physiology·Zebo Huang, Alan Tunnacliffe
Nov 15, 2012·Fungal Genetics and Biology : FG & B·Carmen Herrero de DiosJesús Pla
Jan 6, 2016·Plant Reproduction·Said HafidhDavid Honys
Oct 5, 2010·European Journal of Medicinal Chemistry·Parameswaran SaravananVikash Kumar Dubey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.