Phylogenetic and Metabolic Tracking of Gut Microbiota during Perinatal Development

PloS One
Federica Del ChiericoLorenza Putignani

Abstract

The colonization and development of gut microbiota immediately after birth is highly variable and depends on several factors, such as delivery mode and modality of feeding during the first months of life. A cohort of 31 mother and neonate pairs, including 25 at-term caesarean (CS) and 6 vaginally (V) delivered neonates (DNs), were included in this study and 121 meconium/faecal samples were collected at days 1 through 30 following birth. Operational taxonomic units (OTUs) were assessed in 69 stool samples by phylogenetic microarray HITChip and inter- and intra-individual distributions were established by inter-OTUs correlation matrices and OTUs co-occurrence or co-exclusion networks. 1H-NMR metabolites were determined in 70 stool samples, PCA analysis was performed on 55 CS DNs samples, and metabolome/OTUs co-correlations were assessed in 45 CS samples, providing an integrated map of the early microbiota OTUs-metabolome. A microbiota "core" of OTUs was identified that was independent of delivery mode and lactation stage, suggesting highly specialized communities that act as seminal colonizers of microbial networks. Correlations among OTUs, metabolites, and OTUs-metabolites revealed metabolic profiles associated with early microb...Continue Reading

References

Jan 1, 1977·Annual Review of Microbiology·D C Savage
Mar 1, 1988·Scandinavian Journal of Gastroenterology·H S RasmussenP B Mortensen
Jan 1, 1986·Microbiology and Immunology·Y BennoT Mitsuoka
Nov 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·C CatassiP L Giorgi
May 1, 1996·Applied and Environmental Microbiology·T L Miller, M J Wolin
Jan 1, 1997·Scandinavian Journal of Gastroenterology. Supplement·G T Macfarlane, S Macfarlane
Jan 5, 2002·Applied and Environmental Microbiology·Christine F FavierAntoon D L Akkermans
Feb 14, 2003·Lancet·Francisco Guarner, Juan-R Malagelada
Sep 23, 2003·Nucleic Acids Research·Paul K TanMargaret C Cam
Sep 28, 2005·Current Microbiology·Esther JiménezJuan M Rodríguez
Feb 4, 2006·Journal of Pediatric Gastroenterology and Nutrition·Miguel GueimondeSeppo Salminen
Feb 4, 2006·Journal of Pediatric Gastroenterology and Nutrition·Nancy F KrebsK Michael Hambidge
Aug 5, 2006·Anaerobe·Christine F FavierAntoon D L Akkermans
Aug 10, 2006·Chemical Reviews·Stephen W Ragsdale
Feb 3, 2007·Journal of Proteome Research·Julian R MarchesiYulan Wang
Jun 28, 2007·PLoS Biology·Chana PalmerPatrick O Brown
Oct 19, 2007·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 7, 2007·Journal of Proteome Research·Jasmina SaricElaine Holmes
Feb 2, 2008·Nature Reviews. Drug Discovery·Wei JiaJeremy K Nicholson
Feb 19, 2008·Current Opinion in Chemical Biology·Jesse ZaneveldRob Knight
Jun 4, 2008·Biological & Pharmaceutical Bulletin·Jenny PetterssonLars Bohlin
Sep 29, 2009·The Journal of Pediatrics·Maka MshvildadzeVolker Mai
Mar 25, 2010·Genome Biology and Evolution·Parag A VaishampayanM Pilar Francino
Apr 17, 2010·Journal of Agricultural and Food Chemistry·Angela MarcobalDavid A Mills
May 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·Matteo FallaniUNKNOWN Other Members of the INFABIO Team
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maria G Dominguez-BelloRob Knight
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Jul 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jeremy E KoenigRuth E Ley
Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ryan A Chisholm, Stephen W Pacala
Oct 22, 2010·The Journal of Pediatrics·Aurelien JacquotJean-Charles Picaud
Nov 3, 2010·Current Opinion in Microbiology·Bärbel Stecher, Wolf-Dietrich Hardt
Nov 13, 2010·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Leo LahtiSamuel Kaski
Mar 1, 2011·Trends in Endocrinology and Metabolism : TEM·Thomas Greiner, Fredrik Bäckhed
Jun 21, 2011·Annual Review of Microbiology·Jens Walter, Ruth Ley
Sep 23, 2011·Nature·Stephanie K LathropChyi-Song Hsieh
Nov 15, 2011·Current Opinion in Gastroenterology·Vincent B Young

❮ Previous
Next ❯

Citations

Jul 30, 2016·Gut Microbes·Hans RaskovJacob Rosenberg
Sep 7, 2016·Frontiers in Microbiology·Silvia ArboleyaR Paul Ross
Sep 22, 2016·Journal of Proteome Research·Flaminia Cesare MarincolaMauro Stronati
Dec 14, 2016·Current Microbiology·Quanjiang DongShiying Xuan
Dec 10, 2016·Critical Reviews in Microbiology·Lisa F StinsonJeffrey A Keelan
May 3, 2016·International Journal of Molecular Sciences·Silvia ArboleyaMiguel Gueimonde
Jan 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia Torow, Mathias W Hornef
Dec 31, 2015·Nutrition and Metabolic Insights·Aifric O'SullivanJennifer T Smilowitz
Dec 19, 2017·Frontiers in Immunology·Dagbjort H PetursdottirEva Sverremark-Ekström
Jul 21, 2017·Beneficial Microbes·G ReidS van Hemert
Jul 29, 2017·The Journal of Endocrinology·Christopher M Mulligan, Jacob E Friedman
Nov 6, 2018·FEMS Microbiology Ecology·Vanesa Natalin Rocha MartinChristophe Lacroix
Nov 10, 2017·Microbiology and Molecular Biology Reviews : MMBR·Christian MilaniMarco Ventura
Sep 14, 2016·Journal of Clinical Gastroenterology·Antonio TursiGiovanni Brandimarte
Aug 31, 2020·Microbial Biotechnology·Giulia AlessandriMarco Ventura
Oct 22, 2019·Frontiers in Immunology·Giulia AlessandriMarco Ventura
Apr 15, 2020·Nature Microbiology·Kyle BittingerGary D Wu
Apr 10, 2016·Environmental Microbiology·Kacy GreenhalghPaul Wilmes
Mar 9, 2018·Frontiers in Microbiology·Lisa F StinsonMatthew S Payne
Sep 8, 2018·Nutrients·Laura Di FrancescoLorenza Putignani
Mar 12, 2020·Frontiers in Cellular and Infection Microbiology·Lorenza RomaniFabio Fusaro
Nov 30, 2018·Molecular Medicine Reports·Junfeng WangShan Zheng
Oct 13, 2020·FEMS Microbiology Ecology·Ana Margarida PereiraAna Rita J Cabrita
Nov 3, 2020·Antonie van Leeuwenhoek·Eman Zakaria Gomaa
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Viola SennTanja Restin
May 14, 2021·Frontiers in Pediatrics·Yan SunChunming Jiang
Oct 1, 2021·Journal of Proteome Research·Liene BervoetsJohn Penders

❮ Previous
Next ❯

Methods Mentioned

BETA
Cesarean section
NMR
PCA
Feature Extraction

Software Mentioned

HITChip
Sigmaplot
Cytoscape
MCODE
Agilent Feature Extraction
CAMO
R
UnscrublerX
GraphPad Prism
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.