Phylogenetic characterization of Dengue virus type 2 in Espírito Santo, Brazil.

Molecular Biology Reports
Raquel Spinassé Dettogni, Iúri Drumond Louro

Abstract

Over the last decade, the Espírito Santo State, Brazil has become an endemic Dengue fever location with annual outbreaks of varying magnitude. It is still unclear which geographical route allowed the virus entry in the state and how it has genetically changed since then. Therefore we have set out to study the local molecular constitution of the virus and determine phylogenetic similarities and differences with other Brazilian locations, as well as locations worldwide. Viral envelope genes were partially sequenced from Dengue patients during the 2009 epidemic. We were able to determine that local strains were of American/Asian genotype and closely related to viruses circulating in Rio de Janeiro and São Paulo states during the 2007, 2008 and 2009 epidemics. Genetic divergence analysis showed that the American/Asian genotype is evolutionarily closer to the Asian II genotype and distant from the Sylvatic genotype. Sequenced strains were not 100% similar and showed a high evolutionary conservation of the fusion peptide in the dimerization domain of E protein. This is the first molecular description of circulating Dengue virus strains in the Espírito Santo State, Brazil and should help monitor and control local Dengue outbreaks.

References

Oct 1, 1991·Journal of Clinical Microbiology·K MoritaA Igarashi
Jan 1, 1990·Annual Review of Microbiology·T J ChambersC M Rice
Mar 1, 1988·The Journal of General Virology·P J WalkerB M Gorman
Jan 1, 1994·The Journal of General Virology·R S LanciottiD W Trent
Nov 1, 1993·Virology·J A LewisD W Trent
May 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·P F VasconcelosJ F da Rosa
May 1, 1995·Memórias do Instituto Oswaldo Cruz·R V de SouzaH G Schatzmayr
Jul 1, 1995·The Journal of General Virology·E ChungueV Deubel
Sep 18, 1997·The Journal of General Virology·R S LanciottiD W Trent
Feb 6, 1998·The American Journal of Tropical Medicine and Hygiene·R Rico-HesseF A Ennis
Nov 27, 1998·Memórias do Instituto Oswaldo Cruz·M P MiagostovichR S Lanciotti
Feb 27, 2001·Virology·A C ShurtleffA D Barrett
Dec 10, 2002·Memórias do Instituto Oswaldo Cruz·Flávia Barreto dos SantosEva Harris
Dec 31, 2003·Advances in Virus Research·Rebeca Rico-Hesse
Feb 12, 2005·Emerging Infectious Diseases·João Bosco SiqueiraDouglas L Hatch
Jun 4, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R J Pires NetoB A L Fonseca
Nov 12, 2005·Journal of Virology·Christine V F CarringtonEdward C Holmes
Mar 11, 2006·The Journal of General Virology·Chunlin ZhangEdward C Holmes
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jan 17, 2008·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Rita Maria Ribeiro NogueiraHermann Gonçalves Schatzmayr
Sep 16, 2009·Annals of the New York Academy of Sciences·Scott B Halstead
Mar 6, 2010·Emerging Infectious Diseases·Michelli Faria OliveiraRita Maria Ribeiro Nogueira
Aug 3, 2010·PloS One·Camila Malta RomanoClaudio Sergio Pannuti

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