Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae

Yeast
B el MoualijF E Sluse

Abstract

The screening of the open reading frames identified in the whole yeast genome has allowed us to discover 34 proteins belonging to the mitochondrial carrier family. By phylogenetic study, they can be divided into 27 subfamilies including ADP/ATP, phosphate and citrate carriers, putative oxoglutarate and GDC carriers and 22 new subfamilies. Topology predictions using the 'positive inside rule' approach have shown that the yeast carriers are similarly oriented with both extremities exposed to the cytosol. In each subfamily, a strict conservation of the charged residues in the six transmembrane alpha-helices is observed, suggesting a functional role for these residues and the existence of 27 functionally distinct carriers.

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Citations

Jul 9, 2005·Eukaryotic Cell·Valeria Cizewski CulottaMatthew D Hall
Dec 19, 2012·Antioxidants & Redox Signaling·Tiago R FigueiraAnibal E Vercesi
Sep 2, 2008·FEMS Microbiology Reviews·Margarida CasalIsabel Soares-Silva
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Apr 1, 2004·The Journal of Biological Chemistry·Araceli del Arco, Jorgina Satrústegui
Jan 16, 2003·FEBS Letters·Petr Jezek, Jan Jezek
Jan 22, 2002·FEBS Letters·Francis E Sluse, Wieslawa Jarmuszkiewicz
Aug 7, 2003·The Journal of Biological Chemistry·Ulrich MühlenhoffGerlinde Wiesenberger
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Oct 1, 2003·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Edward LukValeria C Culotta
Sep 7, 2014·Heart Failure Reviews·Alexander T AkhmedovJosé Marín-García
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