Phylogenetic distribution of streptococcal superantigen SSA allelic variants provides evidence for horizontal transfer of ssa within Streptococcus pyogenes.

Infection and Immunity
K B RedaR Rich R

Abstract

Phylogenetic analyses recently found the gene encoding the streptococcal superantigen SSA of Streptococcus pyogenes to occur in several well-differentiated clones comprising 10 (12.5%) of 80 clonal lineages examined. To determine if distinct clonal lineages carried the same ssa coding sequence or harbored a group of allelic variants, ssa was sequenced from 23 S. pyogenes strains representing the 10 clones identified by multilocus enzyme electrophoresis. Three alleles of ssa were found in natural populations of S. pyogenes. ssa-1 and ssa-3 differed by a single synonymous substitution in codon 94; both encoded SSA-1. Each of these alleles was present in phylogenetically diverse clones that had not shared a recent common ancestor. ssa-2 was present in a single clonal lineage. It was identical to ssa-3 at codon 94 but had a nonsynonymous substitution at codon 28 that changed the second amino acid of the mature protein from serine to arginine. This substitution altered the predicted isoelectric point and affected the apparent molecular mass during sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Despite sequence variation both upstream of and within the ssa locus, all ssa-positive lineages expressed either SSA-1 or SSA-2. ...Continue Reading

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Citations

Feb 22, 2001·The Journal of Clinical Investigation·S D ReidJ M Musser
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Stephen B BeresJames M Musser
Jan 9, 2008·The Journal of Infectious Diseases·Ivo VojtekEmmanuelle Charpentier
Sep 24, 2008·Journal of Medical Microbiology·Robert CommonsNigel Curtis
Aug 1, 1997·FEMS Immunology and Medical Microbiology·R Krause
Oct 26, 2007·Journal of Clinical Microbiology·Bogdan Luca-HarariAftab Jasir
Dec 10, 2003·Journal of Clinical Microbiology·Rebecca J TowersGursharan S Chhatwal

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