Phylogenetic diversity of human pathogenic Fusarium and emergence of uncommon virulent species

The Journal of Infection
Husam SalahSaad J Taj-Aldeen

Abstract

Fusarium species cause a broad spectrum of infections. However, little is known about the etiological agents to the species level. We identified Fusarium species isolated from clinical specimens including those of high risk patients to better understand the species involved in the pathogenesis. A set of 44 Fusarium isolates were identified by two-locus sequence typing using partial sequences of the second largest subunit of RNA polymerase (RPB2) and translation elongation factor 1 alpha (TEF-1α). The identified species belonged to four species complexes (SC); the most common SC was Fusarium solani (FSSC) (75%), followed by Fusarium oxysporum (FOSC) (4.5%), Fusarium fujikuroi (FFSC) (13.6%), and Fusarium dimerum (FDSC) (6.8%). Sites of infections were nails (n = 19, 43.2%), skin (n = 7, 15.9%), cornea (n = 6, 13.6%), blood (n = 3, 9%), wound (n = 4, 6.8%), burn (n = 2, 4.5%), tissue (n = 2, 4.5%), and urine (n = 1, 2.27%). Fusarium acutatum was rare and seem restricted to the Middle East. Comorbidities associated with invasive infections were hematological malignancy and autoimmune disorders. Members of the FSSC predominantly caused cornea, nail and bloodstream infections. Less frequently encountered were the FOSC, FFSC and FDSC...Continue Reading

References

Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·K O'DonnellR C Ploetz
Nov 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J AnaissieT J Walsh
Mar 7, 2002·Journal of Clinical Microbiology·Valérie Letscher-BruRaoul Herbrecht
Sep 23, 2003·The Journal of Burn Care & Rehabilitation·Barbara A Latenser
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio NucciElias Anaissie
Sep 7, 2004·Veterinary Pathology·J EvansH E Jensen
Oct 9, 2004·Journal of Clinical Microbiology·Patricio GodoyArnaldo Lopes Colombo
Apr 15, 2006·Clinical Microbiology Reviews·Deirdre ChurchRobert Lindsay
Jun 15, 2006·Journal of Medical Microbiology·D A EnochN M Brown
Aug 24, 2006·JAMA : the Journal of the American Medical Association·Douglas C ChangUNKNOWN Fusarium Keratitis Investigation Team
Sep 13, 2006·Medical Mycology·Saad J Taj-AldeenJosep Guarro
Oct 7, 2006·Mycoses·Ursula KabenKathrin Tintelnot
Oct 16, 2007·Clinical Microbiology Reviews·Marcio Nucci, Elias Anaissie
Feb 12, 2008·The Journal of Antimicrobial Chemotherapy·Ana Alastruey-IzquierdoJuan Luís Rodríguez-Tudela
Apr 30, 2008·Antimicrobial Agents and Chemotherapy·Anna Maria TortoranoMaria Anna Viviani
May 15, 2009·Clinical and Experimental Dermatology·N S CookeS Dempsey
Sep 1, 2009·Fungal Genetics and Biology : FG & B·Kerry O'DonnellBrice A J Sarver
Apr 1, 2011·Journal of Clinical Microbiology·Srilatha EdupugantiKerry O'Donnell
Nov 28, 2012·Revista iberoamericana de micología·Carmen ColladoMaría Francisca Colom
Aug 13, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Guarro
Sep 17, 2013·Clinical Ophthalmology·Rafael A OechslerAna Luisa Hofling-Lima
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M NucciE Anaissie
Oct 23, 2013·Medicine·Maged MuhammedEleftherios Mylonakis
Dec 10, 2013·Hematology·Thomas J Walsh, Maria N Gamaletsou
Feb 20, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A M TortoranoC Lass-Flörl
Oct 14, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Vivian Iida Avelino-SilvaYana Sarkis Novis
Dec 9, 2014·Journal of Neurological Surgery Reports·Asa PetersonGabriel Zada
Dec 30, 2014·The Journal of Antimicrobial Chemotherapy·Abdullah M S Al-HatmiJacques F Meis
Mar 3, 2015·Mycoses·László KredicsUNKNOWN Indo-Hungarian Fungal Keratitis Working Group

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Citations

Jun 18, 2016·Diagnostic Microbiology and Infectious Disease·Saad J Taj-AldeenCornelia Lass-Flörl
Apr 14, 2016·Genome Biology and Evolution·Yanfang ShangChengshu Wang
Dec 27, 2016·The Journal of Infection·Daniela ValleriniLeonardo Potenza
Nov 21, 2017·F1000Research·Anna SkiadaMaria Drogari-Apiranthitou
Mar 6, 2018·MicrobiologyOpen·Manuela MurgiaMohammed N Al-Ahdal
Feb 9, 2019·Mycopathologia·Ziauddin KhanSoumya Varghese
Apr 27, 2019·Frontiers in Microbiology·Patricia F HerkertJacques F Meis
Jan 1, 2018·European Journal of Plant Pathology·Moslem PapizadehHossein Ramezani
Apr 23, 2020·Frontiers in Cellular and Infection Microbiology·Claudy Oliveira Dos SantosCathrien A Eggink
Apr 30, 2021·Saudi Journal of Biological Sciences·Mervat Morsy Abbas Ahmed El-GendyAhmed Mohamed Ahmed El-Bondkly
Jun 9, 2020·Mycopathologia·Mohammad Javad NajafzadehAbdullah M S Al-Hatmi

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