Phylogenetic footprint analysis of IGF2 in extant mammals

Genome Research
Jennifer R WeidmanR L Jirtle

Abstract

Genomic imprinting results in monoallelic gene transcription that is directed by cis-acting regulatory elements epigenetically marked in a parent-of-origin-dependent manner. We performed phylogenetic sequence and epigenetic comparisons of IGF2 between the nonimprinted platypus (Ornithorhynchus anatinus) and imprinted opossum (Didelphis virginiana), mouse (Mus musculus), and human (Homo sapiens) to determine if their divergent imprint status would reflect differences in the conservation of genomic elements important in the regulation of imprinting. We report herein that IGF2 imprinting does not correlate evolutionarily with differential intragenic methylation, nor is it associated with motif 13, a reported IGF2-specific "imprint signature" located in the coding region. Instead, IGF2 imprinting is strongly associated with both the lack of short interspersed transposable elements (SINEs) and an intragenic conserved inverted repeat that contains candidate CTCF-binding sites, a role not previously ascribed to this particular sequence element. Our results are the first to demonstrate that comparative footprint analysis of species from evolutionarily distant mammalian clades, and exhibiting divergent imprint status is a powerful bioin...Continue Reading

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Citations

Feb 9, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jennifer R WeidmanRandy L Jirtle
Jul 27, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hasan KhatibEui-Soo Kim
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Oct 16, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Radhika DasRandy L Jirtle
Oct 12, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mary J O'ConnellCharles Spillane
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Jul 27, 2021·Experimental Biology and Medicine·Kenneth S RamosEmma Bowers

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