Phylogenetic lineages, clones and β-lactamases in an international collection of Klebsiella oxytoca isolates non-susceptible to expanded-spectrum cephalosporins

The Journal of Antimicrobial Chemotherapy
R IzdebskiMOSAR WP2 WP3 and WP5 Study Groups

Abstract

The objective of this study was to examine Klebsiella oxytoca clonal and phylogenetic diversity, based on an international collection of carriage isolates non-susceptible to expanded-spectrum cephalosporins (ESCs). The study material comprised 68 rectal carriage K. oxytoca isolates non-susceptible to ESCs recovered in 2008-11 from patients in 14 hospitals across Europe and Israel. ESC resistance was tested phenotypically; genes encoding ESBLs, AmpC cephalosporinases and carbapenemases were amplified and sequenced. The isolates were typed by PFGE and MLST, followed by sequencing of blaOXY genes. MLST and PFGE distinguished 34 STs and 47 pulsotypes among the isolates, respectively. Six STs were split into several pulsotypes each. Five STs were more prevalent (n = 2-9) and occurred in several countries each, including ST2, ST9 and ST141, which belong to a growing international clonal complex (CC), CC2. Four phylogenetic lineages were distinguished, each with another type of chromosomal OXY-type β-lactamase. Three of these, with OXY-1/-5, OXY-2 types and OXY-4, corresponded to previously described phylogroups KoI, KoII and KoIV, respectively. A single isolate from Israel represented a distinct lineage with a newly defined OXY-7 typ...Continue Reading

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Citations

Oct 9, 2016·Applied Microbiology and Biotechnology·Karolina Stojowska-Swędrzyńska, Beata Krawczyk
Dec 6, 2017·International Journal of Systematic and Evolutionary Microbiology·Virginie Passet, Sylvain Brisse
Apr 3, 2019·Antimicrobial Agents and Chemotherapy·María Pérez-VazquezUNKNOWN Spanish Antibiotic Resistance Surveillance Program Collaborating Group
Jun 6, 2020·Microbiology Resource Announcements·Clement K M TsuiAndres Perez-Lopez
Jul 26, 2018·Frontiers in Microbiology·Veronika PaskovaJaroslav Hrabak
Nov 12, 2019·Frontiers in Microbiology·Cristina MerlaSylvain Brisse
Apr 2, 2021·Journal of Clinical Microbiology·José Manuel Ortiz de la RosaPatrice Nordmann

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