Phylogenetic reconstruction of HCV genotype 1b dissemination in a small city centre: the Camporeale model

Journal of Medical Virology
Donatella FerraroRosa Di Stefano

Abstract

Several seroepidemiological population-based surveys carried out in Italy have shown a high prevalence of hepatitis C virus (HCV) infection. Camporeale (CP), a small Sicilian town with a 10.4% prevalence of HCV mostly genotype 1b, probably represents a specific context, since intravenous drug addiction, and sexual promiscuity are almost absent. In order to reconstruct the pattern of introduction and diffusion of HCV in this ecological niche, the NS5 genomic region of 72 HCV genotype 1 isolates (39 from CP and 33 collected throughout Sicily) was amplified and sequenced. Sequences were aligned and analyzed by BioEdit, PAUP and BEAST, and their molecular evolution compared. Thirty-eight HCV genotype 1b isolates from CP were associated in a monophyletic "transmission cluster." By applying Monte Carlo Markov simulation, it was calculated that HCV was introduced between the end of the 1940s and the beginning of the 1950s. The phylogenetic distance between the CP cluster and other Sicilian isolates confirmed its uniqueness and the local diffusion from a common ancestor. The data obtained from classic phylogenetic analysis, combined with the application of the Bayesian analysis to the study of the coalescence of phylogenetic trees, hav...Continue Reading

References

Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Simmonds
Jun 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R C Griffiths, S Tavaré
Jun 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E DomingoJ J Holland
Sep 1, 1996·The Journal of General Virology·A RuggieriM Rapicetta
Jan 1, 1995·Annual Review of Genetics·P Donnelly, S Tavaré
Feb 1, 1997·The Journal of General Virology·D B SmithP Simmonds
Jul 1, 1997·Journal of Hepatology·A R OsellaG Fiore
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V GuadagninoM Piazza
Apr 30, 1998·Genetics·J W DrakeJ F Crow
Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A G RodrigoJ I Mullins
Jul 15, 2000·Seminars in Liver Disease·A Wasley, M J Alter
Jun 26, 2001·Science·O G PybusP H Harvey
Dec 26, 2001·Bioinformatics·S KumarM Nei
Jul 13, 2002·Journal of Medical Virology·Rosa Di StefanoAntonio Craxì
Oct 16, 2004·The Journal of General Virology·Peter Simmonds
Dec 25, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsJuan Rodés
Jan 11, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Oliver G PybusPeter Simmonds
May 20, 2005·Journal of Medical Virology·Filippo AnsaldiGiancarlo Icardi
Apr 14, 2006·Journal of Virology·Jannick VerbeeckMarc Van Ranst

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Citations

Nov 7, 2009·European Journal of Public Health·Emanuele AmodioNino Romano
Nov 28, 2012·BMC Infectious Diseases·Massimo CiccozziMarco Ciotti
Mar 31, 2009·Future Microbiology·Claudio ArgentiniMaria Rapicetta
Jul 29, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Elisabeth LampeGonzalo Bello
Apr 22, 2009·Journal of Medical Virology·Paola PizzilloRosa Di Stefano
Sep 28, 2010·Journal of Medical Virology·Mónica Viviana Alvarado MoraJoão Renato Rebello Pinho
Mar 30, 2012·The Journal of General Virology·Joseph C ForbiYury E Khudyakov
Feb 11, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Donatella FerraroAntonio Craxì
Mar 13, 2015·Archives of Virology·Federico Alejandro Di LelloViviana Elizabeth Ré
Jul 7, 2009·Scandinavian Journal of Infectious Diseases·Andrea MarianoAlfonso Mele

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