Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions.

The Journal of Infectious Diseases
Alison E BrownConcerted Action on Seroconversion to AIDS and Death in Europe (CASCADE) Collaboration

Abstract

Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

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Citations

May 26, 2011·Nature Communications·Mattia C F ProsperiUNKNOWN ARCA collaborative group
Oct 24, 2013·The Journal of Infectious Diseases·Joel O WertheimSergei L Kosakovsky Pond
Jun 15, 2010·Current Opinion in HIV and AIDS·William C MillerKimberly A Powers
Dec 17, 2009·AIDS·Daniela BezemerUNKNOWN ATHENA observational cohort
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Dec 18, 2013·PLoS Medicine·Timothy B Hallett
Feb 22, 2012·PloS One·Pierre FrangeUNKNOWN French ANRS CO6 PRIMO Cohort Study Group
Dec 5, 2012·PloS One·Steven M GoodreauSusan P Buchbinder
Aug 28, 2015·The Journal of Infectious Diseases·Amitabh B SutharBrian G Williams
Jun 15, 2010·Current Opinion in HIV and AIDS·Elizabeth HamlynSarah Fidler
Jun 18, 2009·Current Opinion in HIV and AIDS·David PaoMartin Fisher
Jan 5, 2014·Current Opinion in HIV and AIDS·Mary K Grabowski, Andrew D Redd
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Jul 12, 2017·Journal of the International AIDS Society·Sarah E RutsteinJoseph D Tucker
Jun 3, 2021·The Journal of Infectious Diseases·Manon Ragonnet-CroninUNKNOWN with the PANGEA Consortium

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