Phylogenetic tracing and biological characterization of a novel clade 2.3.2.1 reassortant of H5N6 subtype avian influenza virus in China.

Transboundary and Emerging Diseases
Zhichuang GeXiufan Liu

Abstract

In recent years in China, clade 2.3.4.4 H5N6 plus clade 2.3.2.1 H5N1 subtype highly pathogenic avian influenza (HPAI) viruses have gradually become endemic in poultry, and their co-circulation could inevitably facilitate the gene reassortment between each other. During our routine surveillance in live poultry markets (LPMs) in eastern China in 2017-2018, a novel reassortant H5N6 strain with the HA gene derived from clade 2.3.2.1 was isolated from the cloacal swabs of apparently healthy ducks. Phylogenetic tracing analysis indicated that another two clade 2.3.2.1 H5N1 strains with divergent lineages of PB1 gene and one clade 2.3.4.4 H5N6 isolate of the dominant genotype sharing spatio-temporal proximity were intimately involved in the generation of this rarely reported clade 2.3.2.1 H5N6 reassortant. Distinct with the other three HPAI H5 viruses showing moderate virulence in mice, the H5N1 strain of the homologous internal gene constellation against the clade 2.3.2.1 H5N6 reassortant was highly pathogenic, which might probably attribute to the H3 subtype-derived PB1 gene. However, as compared to the clade 2.3.4.4 H5N6 ancestor, the clade 2.3.2.1 H5N6 reassortant displayed a broader tissue distribution and higher viral titres in ...Continue Reading

References

Jan 29, 2002·Archives of Virology·E HoffmannD R Perez
Mar 7, 2009·Journal of Virology·Quynh Mai LeYoshihiro Kawaoka
May 7, 2009·The Journal of Infectious Diseases·Lei ZhouHongjie Yu
Jun 4, 2010·Influenza and Other Respiratory Viruses·Tara AndersonAlex Thiermann
Jul 31, 2014·Emerging Infectious Diseases·Haibo WuNanping Wu
May 13, 2015·Influenza and Other Respiratory Viruses·Gavin J D SmithUNKNOWN World Health Organization/World Organisation for Animal Health/Food and Agriculture Organization (WHO/OIE/FAO) H5 Evolution
Jun 18, 2016·Emerging Infectious Diseases·Dong-Hun LeeDavid E Swayne
Dec 6, 2016·Cell Host & Microbe·Yuhai BiGeorge Fu Gao
Dec 23, 2016·Journal of Virology·Lei YangYuelong Shu
Jan 13, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Young-Jae SiYoung-Ki Choi
Sep 2, 2017·Journal of Veterinary Science·Dong-Hun LeeDavid E Swayne
Jan 31, 2018·Emerging Infectious Diseases·Nancy BeerensArmin Elbers
May 1, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yu-Pin LiuMing-Shiuh Lee
Sep 19, 2018·Emerging Infectious Diseases·Jung-Hoon KwonChang-Seon Song

❮ Previous
Next ❯