Phylogenetic, virological, and clinical characteristics of genotype C hepatitis B virus with TCC at codon 15 of the precore region

Journal of Clinical Microbiology
H L ChanJoseph J Y Sung

Abstract

Hepatitis B virus (HBV) with T-1856 of the precore region is always associated with C-1858 (i.e., TCC at nucleotides 1856 to 1858), and it is reported only in genotype C HBV isolates. We aimed to investigate the phylogenetic, virological, and clinical characteristics of HBV isolates bearing TCC at nucleotides 1856 to 1858. We have previously reported on the presence of two major subgroups in genotype C HBV, namely, HBV genotype Cs (Southeast Asia) and HBV genotype Ce (Far East). We have designed a novel 5' nuclease technology based on the nucleotide polymorphism (C or A) at nucleotide 2733 to differentiate the two genotype C HBV subgroups. The mutations at the basal core promoter and precore regions were analyzed by direct sequencing. Among 214 genotype C HBV-infected patients, 31% had TCC, 37% had CCC, 3% had CTC, and 29% had CCT at nucleotides 1856 to 1858. All except one HBV strain with TCC at nucleotides 1856 to 1858 belonged to subgroup Cs, which has been reported only in Hong Kong; Guangzhou, China; and Vietnam. HBV with TCC at nucleotides 1856 to 1858 was associated with the G1898A mutation (64%). Patients infected with HBV harboring TCC had more liver cirrhosis than those infected with HBV harboring CCC (18% versus 5%; ...Continue Reading

References

Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Rodriguez-FriasJ Guardia
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·A S LokS Greene
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U S AkarcaA S Lok
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K R LoebL Corey
Aug 30, 2001·Journal of Clinical Microbiology·E AlestigM Lindh
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E OritoM Mizokami
Jan 5, 2002·Journal of Clinical Microbiology·Jia-Horng KaoDing-Shinn Chen
Jul 19, 2002·The Journal of General Virology·Patricia Arauz-RuizLars O Magnius
Sep 17, 2003·Journal of Gastroenterology and Hepatology·Seiji SuzukiMasashi Mizokami
Feb 11, 2004·The Journal of General Virology·Tran Thien-Tuan HuyKenji Abe
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shuang-Yuan KuangJohn D Groopman
Apr 2, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Tran T T Huy, Kenji Abe
Jul 20, 2004·World Journal of Gastroenterology : WJG·Mayumi SakuraiMasashi Mizokami
Feb 17, 2005·Journal of the National Cancer Institute·Ming-Whei YuChien-Jen Chen
May 18, 2005·The Journal of Infectious Diseases·Henry L Y ChanJoseph J Y Sung

❮ Previous
Next ❯

Citations

Mar 23, 2007·Journal of Clinical Microbiology·Zhanhui WangJinlin Hou
Aug 20, 2010·Cellular Immunology·Saad ZakyMahmoud Rezk Abdelwahed Hussein
Aug 18, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Henry Lik-Yuen ChanVincent Wai-Sun Wong
Nov 20, 2013·Journal of Medical Virology·Maria NordinKarin Kidd-Ljunggren
Apr 25, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jing YuanMasashi Mizokami
Jan 12, 2013·Alimentary Pharmacology & Therapeutics·G L-H WongV W-S Wong
Jan 15, 2011·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Kwong-Sak LeungJoseph Jao-Yiu Sung
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry Lik-Yuen ChanTony Shu-Kam Mok
Jun 4, 2010·Arquivos De Gastroenterologia·Carlos Eduardo BeckerNelson Alexandre Kretzmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.