Phylogeny and evolution of class-I helical cytokines

The Journal of Endocrinology
Mark O HuisingGert Flik

Abstract

The class-I helical cytokines constitute a large group of signalling molecules that play key roles in a plethora of physiological processes including host defence, immune regulation, somatic growth, reproduction, food intake and energy metabolism, regulation of neural growth and many more. Despite little primary amino acid sequence similarity, the view that all contemporary class-I helical cytokines have expanded from a single ancestor is widely accepted, as all class-I helical cytokines share a similar three-dimensional fold, signal via related class-I helical cytokine receptors and activate similar intracellular signalling cascades. Virtually all of our knowledge on class-I helical cytokine signalling derives from research on primate and rodent species. Information on the presence, structure and function of class-I helical cytokines in non-mammalian vertebrates and non-vertebrates is fragmentary. Consequently, our ideas about the evolution of this versatile multigene family are often based on a limited comparison of human and murine orthologs. In the last 5 years, whole genome sequencing projects have yielded draft genomes of the early vertebrates, pufferfish (Takifugu rubripes), spotted green pufferfish (Tetraodon nigrovirid...Continue Reading

Citations

Jun 19, 2008·Immunogenetics·Maki OhtaniJohannes Martinus Dijkstra
Jul 16, 2008·Marine Biotechnology·Steven RobertsFrederick Goetz
May 5, 2009·Médecine sciences : M/S·Jean-Pierre Levraud, Pierre Boudinot
Sep 8, 2010·Médecine sciences : M/S·Franck Oury, Gérard Karsenty
Apr 30, 2010·The Journal of Biological Chemistry·Jeffery L Voorhees, Charles L Brooks
Aug 28, 2007·Journal of Biomolecular Structure & Dynamics·M Ravishankar RamR Malathi
Jun 12, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Gong ChengZhaoxin Zheng
Feb 28, 2009·Evolution & Development·J S TordayVirender K Rehan
Nov 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Lebris S QuinnJosép M Argilés
Jul 21, 2007·BMC Evolutionary Biology·Clifford Liongue, Alister C Ward
May 12, 2012·Endocrine Reviews·Charles L Brooks
Nov 30, 2012·Molecular Endocrinology·Jie XuStuart J Frank
Oct 5, 2010·PloS One·Carla M S RibeiroGeert F Wiegertjes
Apr 18, 2014·The Journal of Endocrinology·Lauren E MacDonaldNicholas J Bernier
Jul 1, 2014·Journal of Chemical Neuroanatomy·Marnix Gorissen, Gert Flik
May 4, 2011·Stem Cell Reviews and Reports·Marie-Emmanuelle MathieuHélène Bœuf
Jan 29, 2016·Cytokine·Sarah PasquinJean-François Gauchat
Feb 5, 2013·Seminars in Nephrology·Marcin Adamczak, Andrzej Wiecek
Jul 26, 2011·Developmental and Comparative Immunology·Lluis Tort
Jan 26, 2011·General and Comparative Endocrinology·B M L Verburg-van KemenadeM Chadzinska
Oct 17, 2015·Molecular Immunology·Geert F WiegertjesInge R Fink
Sep 17, 2008·Developmental and Comparative Immunology·Linda D RhodesS Ellen Demlow
Jun 3, 2008·Molecular Immunology·Barbara CastellanaJosep V Planas
Jun 10, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Koji MurashitaTadahide Kurokawa
Apr 9, 2008·Developmental and Comparative Immunology·Steven RobertsFrederick Goetz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.