PMID: 611021Apr 1, 1977Paper

Phylogeny of immunoglobulin structure and function; characterization of the cysteine-containing peptide involved in the pentamerization of shark IgM

Developmental and Comparative Immunology
D G Klapper, L W Clem

Abstract

Nurse shark (Ginglymostoma cirratum) immunoglobulins were studied in an attempt to further define the relationship between the naturally occurring monomeric 7S and the pentameric 19S forms of extracellular IgM. A peptide containing the cysteine involved in the formation of intersubunit disulfide bonds linking 7S monomers into pentamers was isolated from the H chain of the 19S molecule and characterized. A similar peptide was also isolated from the H chain of the naturally occurring 7S molecule. These observations serve to substantiate previous claims that the two shark proteins belong to the same immunoglobulin class.

References

Feb 16, 1971·Biochemistry·D G KlapperP A Small
May 1, 1967·The Journal of Experimental Medicine·L W Clem, P A Small
Jan 1, 1969·Advances in Immunology·H M Grey
May 1, 1972·Comparative Biochemistry and Physiology. A, Comparative Physiology·D G Klapper, L W Clem
Sep 13, 1965·Biochimica Et Biophysica Acta·C W Easley

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Citations

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R L RaisonW H Hildemann
Apr 21, 2006·Immunological Reviews·Ellen HsuMartin F Flajnik
Sep 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caitlin D Castro, Martin F Flajnik

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