Phylogeny, recombination and expression of porcine endogenous retrovirus gamma2 nucleotide sequences

The Journal of General Virology
Nikolai KlymiukBernhard Aigner

Abstract

Endogenous retroviral sequences in the pig genome represent a potential infectious risk in xenotransplantation. Porcine endogenous retrovirus (PERV) gamma sequences described to date have been classified into several families. The known infectious, human-tropic PERVs have been assigned to the PERV gamma1 subfamilies A, B and C. High copy numbers and full-length clones have also been observed for an additional family, designated PERV gamma2. The aim of this study was to examine the PERV gamma2 family by analysis of retroviral pro/pol gene sequences. The proviral load was observed to be similar among various pig breeds. Although clones harbouring an open reading frame in the examined region were found, analysis of published large PERV gamma2 clones revealed multiple deleterious mutations in each of the retroviral genes. Various recombination events between gamma2 genomes were revealed. In contrast to PERV gamma1, phylogenetic analyses did not distinguish defined subfamilies, but indicated the independent evolution of the proviruses after a single event of retroviral amplification. Expression analysis showed large PERV gamma2 transcripts and variable transcription in several tissues. Analysis of the two published gamma2 env gene s...Continue Reading

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Oct 22, 2002·Journal of Virology·Nikolai KlymiukBernhard Aigner
Aug 22, 2003·Reviews in Medical Virology·Saema MagreBirke Bartosch
Sep 19, 2003·The Journal of General Virology·Nikolai KlymiukBernhard Aigner
Sep 27, 2003·Journal of Virology·Nikolai KlymiukBernhard Aigner
Dec 19, 2003·Nucleic Acids Research·Alex BatemanSean R Eddy
Dec 21, 2004·Nucleic Acids Research·Aron Marchler-BauerStephen H Bryant
Apr 15, 2005·Virus Genes·Nikolai Klymiuk, Bernhard Aigner

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Citations

Feb 14, 2009·Molecules and Cells·Jae-Won HuhHeui-Soo Kim
Jul 17, 2009·Journal of Virology·Weerachai JaratlerdsiriJaime Gongora
May 26, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Stephanie PlogAchim D Gruber
May 16, 2014·Viruses·Magdalena C KimsaUrszula Mazurek
Jun 14, 2006·Xenotransplantation·Reto M Baertschiger, Leo H Buhler

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